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Pharm Sci. 2022;28(4): 525-540. doi: 10.34172/PS.2022.4

Research Article

Protective Effects of Mirazid on Gentamicin-induced Nephrotoxicity in Rats through Antioxidant, Anti-inflammatory, JNK1/ iNOS, and Apoptotic Pathways; Novel Mechanistic Insights

Samar Antar 1 ORCID, Ahmed Ali Al-Karmalawy 2 * ORCID, Ahmed Mourad 3, Magda Mourad 4, Mennaallah Elbadry 4, Sameh Saber 4, Ahmed Khodir 1 *

Cited by CrossRef: 8

1- Al-Karmalawy A, Nafie M, Shaldam M, Elmaaty A, Antar S, El-Hamaky A, Saleh M, Elkamhawy A, Tawfik H. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. J Med Chem. 2023;66(1):777 [Crossref]
2- Hammoud M, Khattab M, Abdel-Motaal M, Van der Eycken J, Alnajjar R, Abulkhair H, Al‐Karmalawy A. Synthesis, structural characterization, DFT calculations, molecular docking, and molecular dynamics simulations of a novel ferrocene derivative to unravel its potential antitumor activity. Journal of Biomolecular Structure and Dynamics. 2022;:1 [Crossref]
3- Parlak Ak T, Sağıroğlu M, Korkmaz G, Yaman M. Erythropoietin and Hypericum perforatum ameliorate Gentamicin–induced nephrotoxicity in rats. RC FCV-LUZ. 2024;XXXIV(2):1 [Crossref]
4- Bolat I, Terim–Kapakin K, Apaydin Yildirim B, Manavoğlu Kirman E. Protective effect of Helichrysum plicatum on head shock protein inflammation and apoptosis in Gentamicin induced nephrotoxicity. RC FCV-LUZ. 2024;XXXIV(2):1 [Crossref]
5- Hammoud M, Nageeb A, Morsi M, Gomaa E, Elmaaty A, Al-Karmalawy A. Design, synthesis, biological evaluation, and SAR studies of novel cyclopentaquinoline derivatives as DNA intercalators, topoisomerase II inhibitors, and apoptotic inducers. New J Chem. 2022;46(23):11422 [Crossref]
6- Farooq J, Sultana R, Prabhu A, Kayarohanam S, Gupta G, Subramaniyan V. Mitigation of 5-Fluorouracil-Induced Nephrotoxicity: The Protective Role of Thymoquinone and Hesperidin in vitro and in vivo. NRFHH. 2025;5(2):255 [Crossref]
7- Antar S, Ashour N, Sharaky M, Khattab M, Ashour N, Zaid R, Roh E, Elkamhawy A, Al-Karmalawy A. Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments. Biomedicine & Pharmacotherapy. 2023;168:115734 [Crossref]
8- El-Naggar A, Hassan A, Elkaeed E, Alesawy M, Al‐Karmalawy A. Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2. Bioorganic Chemistry. 2022;123:105770 [Crossref]
9- El-Azab M, Al-Karmalawy A, Antar S, Hanna P, Tawfik K, Hazem R. A novel role of Nano selenium and sildenafil on streptozotocin-induced diabetic nephropathy in rats by modulation of inflammatory, oxidative, and apoptotic pathways. Life Sciences. 2022;303:120691 [Crossref]

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