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Pharm Sci. 2017;23(2): 84-94. doi: 10.15171/PS.2017.14

Review

Natural Polysaccharide based Nanoparticles for Drug/Gene Deliv­ery

Sara Salatin 1,2 * , Mitra Jelvehgari 1,3

Cited by CrossRef: 33

1- Alami-Milani M, Salatin S, Rayeni F, Jelvehgari M. Preparation and In Vitro Evaluation of Thermosensitive and Mucoadhesive Hydrogels for Intranasal Delivery of Phenobarbital Sodium . Ther Deliv. 2021;12(6):461 [Crossref]
2- Bayer I. Controlled Drug Release from Nanoengineered Polysaccharides. Pharmaceutics. 2023;15(5):1364 [Crossref]
3- Djošić M, Janković A, Mišković-Stanković V. Electrophoretic Deposition of Biocompatible and Bioactive Hydroxyapatite-Based Coatings on Titanium. Materials. 2021;14(18):5391 [Crossref]
4- Aquinas N, Chithra C, Bhat M. Progress in bioproduction, characterization and applications of pullulan: a review. Polym Bull. 2024;81(14):12347 [Crossref]
5- Fischer D, Dusek N, Hotzel K, Heinze T. The Role of Formamidine Groups in Dextran Based Nonviral Vectors for Gene Delivery on Their Physicochemical and Biological Characteristics. Macromolecular Bioscience. 2021;21(1) [Crossref]
6- Plucinski A, Lyu Z, Schmidt B. Polysaccharide nanoparticles: from fabrication to applications. J Mater Chem B. 2021;9(35):7030 [Crossref]
7- Salatin S, Lotfipour F, Jelvehgari M. A brief overview on nano-sized materials used in the topical treatment of skin and soft tissue bacterial infections. Expert Opinion on Drug Delivery. 2019;16(12):1313 [Crossref]
8- Khodaei R, Bayandori M, Sarpoli L, Souri M, Hasanzade I, Khodaee R, Saeedi S, Kiani J, Karimi M. Synthesis, characterization, and cellular investigation of three smart polymeric nanoparticles as efficient plasmid CRISPR (pCRISPR) delivery vehicles. Adv Nat Sci: Nanosci Nanotechnol. 2024;15(4):045003 [Crossref]
9- Alfei S, Zuccari G. Last Fifteen Years of Nanotechnology Application with Our Contribute. Nanomaterials. 2025;15(4):265 [Crossref]
10- Goni B, Sundram S, Sharma R. Utilization of Polysaccharides-Based Nanoparticles for Gene Delivery: Advances and Prospective. CMS. 2025;18(1):40 [Crossref]
11- Maleki G, Woltering E, Mozafari M. Applications of chitosan-based carrier as an encapsulating agent in food industry. Trends in Food Science & Technology. 2022;120:88 [Crossref]
12- Shokrani H, Shokrani A, Sajadi S, Khodadadi Yazdi M, Seidi F, Jouyandeh M, Zarrintaj P, Kar S, Kim S, Kuang T, Rabiee N, Hejna A, Saeb M, Ramakrishna S. Polysaccharide-based nanocomposites for biomedical applications: a critical review. Nanoscale Horiz. 2022;7(10):1136 [Crossref]
13- Khatami F, Matin M, Danesh N, Bahrami A, Abnous K, Taghdisi S. Targeted delivery system using silica nanoparticles coated with chitosan and AS1411 for combination therapy of doxorubicin and antimiR-21. Carbohydrate Polymers. 2021;266:118111 [Crossref]
14- Rajabzadeh-Khosroshahi M, Khoshfetrat A, Salami-Kalajahi M. A review on pectin-based nanostructures for drug and gene delivery systems. International Journal of Biological Macromolecules. 2025;304:140932 [Crossref]
15- Shahrbabak S, Tayebi-Khorrami V, Fadaei M, Moezzi S, Hasnain M, Nayak A, Askari V. Dextran-based vehicle for gene transfection: A lesson learned by nature. International Journal of Biological Macromolecules. 2025;:145980 [Crossref]
16- Chai L, Fan X, Zuo Y, Zhang B, Nie G, Xie N, Xie Z, Zhang H. Low-dimensional nanomaterials enabled autoimmune disease treatments: Recent advances, strategies, and future challenges. Coordination Chemistry Reviews. 2021;432:213697 [Crossref]
17- Islam M, Raikwar S. Enhancement of Oral Bioavailability of Protein and Peptide by Polysaccharide-based Nanoparticles. PPL. 2024;31(3):209 [Crossref]
18- Alfei S, Schito A, Zuccari G. Nanotechnological Manipulation of Nutraceuticals and Phytochemicals for Healthy Purposes: Established Advantages vs. Still Undefined Risks. Polymers. 2021;13(14):2262 [Crossref]
19- Alves A, Bruinsmann F, Guterres S, Pohlmann A. Organic Nanocarriers for Bevacizumab Delivery: An Overview of Development, Characterization and Applications. Molecules. 2021;26(14):4127 [Crossref]
20- Salatin S, Barar J, Barzegar-Jalali M, Adibkia K, Alami-Milani M, Jelvehgari M. Formulation and Evaluation of Eudragit RL-100 Nanoparticles Loaded In-Situ Forming Gel for Intranasal Delivery of Rivastigmine. Adv Pharm Bull. 2019;10(1):20 [Crossref]
21- Salatin S, Alami-Milani M, Jelvehgari M. Expert Design and Optimization of a Novel Buccoadhesive Blend Film Impregnated with Metformin Nanoparticles. Ther Deliv. 2020;11(9):573 [Crossref]
22- Unnikrishnan B, Maya S, Preethi G, Anusree K, Reshma P, Archana M, Kaustabh M, Sreelekha T. Self-assembled drug loaded glycosyl-protein metal nanoconstruct: Detailed synthetic procedure and therapeutic effect in solid tumor treatment. Colloids and Surfaces B: Biointerfaces. 2020;193:111082 [Crossref]
23- Martínez-Ballesta M, Gil-Izquierdo Á, García-Viguera C, Domínguez-Perles R. Nanoparticles and Controlled Delivery for Bioactive Compounds: Outlining Challenges for New “Smart-Foods” for Health. Foods. 2018;7(5):72 [Crossref]
24- Aleebrahim-Dehkordi E, Heidari-Soureshjani E, Aryan A, Ganjirad Z, Soveyzi F, Hoseinsalari A, Derisi M, Rafieian-Kopaei M. Antiviral Compounds Based on Natural Astragalus polysaccharides (APS): Research and Foresight in the Strategies for Combating SARS-CoV-2 (COVID-19). MRMC. 2022;22(17):2299 [Crossref]
25- Salatin S, Asadi R, Jelvehgari M. Development and Characterization of Sublingual Films for Enhanced Bioavailability of Selegiline Hydrochloride. Ther Deliv. 2021;12(2):159 [Crossref]
26- Alipour M, Firouzi N, Aghazadeh Z, Samiei M, Montazersaheb S, Khoshfetrat A, Aghazadeh M. The osteogenic differentiation of human dental pulp stem cells in alginate-gelatin/Nano-hydroxyapatite microcapsules. BMC Biotechnol. 2021;21(1) [Crossref]
27- Salatin S, Jelvehgari M. Desirability function approach for development of a thermosensitive and bioadhesive nanotransfersome–hydrogel hybrid system for enhanced skin bioavailability and antibacterial activity of cephalexin. Drug Development and Industrial Pharmacy. 2020;46(8):1318 [Crossref]

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