Effect of Crocin and Voluntary Exercise on P53 Protein in Pancreas of Type2 Diabetic Rats

Vajihe Ghorbanzadeh ¹, Mustafa Mohammadi ² * , Gisou Mohaddes ³, Hassan Darishnejad ¹, Leila Chodari ⁴

Cited by CrossRef: 16

1- SAEDMOCHESHI S, SAGHEBJOO M, VAHABZADEH Z, SHEIKHOLESLAMI-VATANI D. Aerobic Training and Green Tea Extract Protect against N-methyl-N-nitrosourea–induced Prostate Cancer. 2019;51(11):2210 [Crossref]

2- Taghizadeh F, Mehryab F, Mortazavi S, Rabbani S, Haeri A. Thiolated chitosan hydrogel-embedded niosomes: A promising crocin delivery system toward the management of aphthous stomatitis. Carbohydrate Polymers. 2023;318:121068 [Crossref]

3- Oghbaei H, Alipour M, Hamidian G, Ahmadi M, Ghorbanzadeh V, Keyhanmanesh R. Two months sodium nitrate supplementation alleviates testicular injury in streptozotocin‐induced diabetic male rats. Experimental Physiology. 2018;103(12):1603 [Crossref]

4- Behrouz V, Dastkhosh A, Hedayati M, Sedaghat M, Sharafkhah M, Sohrab G. The effect of crocin supplementation on glycemic control, insulin resistance and active AMPK levels in patients with type 2 diabetes: a pilot study. Diabetol Metab Syndr. 2020;12(1) [Crossref]

5- Sanaie S, Nikanfar S, Kalekhane Z, Azizi-Zeinalhajlou A, Sadigh-Eteghad S, Araj-Khodaei M, Ayati M, Andalib S. Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights. Metab Brain Dis. 2023;38(1):137 [Crossref]

6- Ghaderpour S, Keyhanmanesh R, Hamidian G, Heydari H, Ghiasi F. The effects of voluntary exercise on histological and stereological changes of sciatic nerve, nitric oxide levels, and peripheral neuropathy caused by high-fat diet-induced type 2 diabetes in male rats. Behavioural Brain Research. 2023;451:114507 [Crossref]

7- Mir R, Tyagi A, Hussain S, Almalki M, Zeyad M, Deshmukh R, Ali S. Saffron, a Potential Bridge between Nutrition and Disease Therapeutics: Global Health Challenges and Therapeutic Opportunities. Plants. 2024;13(11):1467 [Crossref]

8- Yaribeygi H, Atkin S, Simental‐Mendía L, Sahebkar A. Molecular mechanisms by which aerobic exercise induces insulin sensitivity. Journal Cellular Physiology. 2019;234(8):12385 [Crossref]

9- Elbassuoni E, Abdel Hafez S. Impact of chronic exercise on counteracting chronic stress-induced functional and morphological pancreatic changes in male albino rats. Cell Stress and Chaperones. 2019;24(3):567 [Crossref]

10- Yaribeygi H, Zare V, Butler A, Barreto G, Sahebkar A. Antidiabetic potential of saffron and its active constituents. Journal Cellular Physiology. 2019;234(6):8610 [Crossref]

11- Sani A, Tajik A, Seiiedi S, Khadem R, Tootooni H, Taherynejad M, Sabet Eqlidi N, Alavi dana S, Deravi N. A review of the anti-diabetic potential of saffron. Nutr Metab Insights. 2022;15 [Crossref]

12- Mafi A, Iraj B, Aarabi M. The beneficial effects of crocin supplementation on metabolic and genetic parameters in type 2 diabetic patients under metformin treatment: A randomized double-blind controlled clinical trial. Journal of Functional Foods. 2024;122:106507 [Crossref]

13- Moradi A, Hosseini S, Nikbakht M. Effect of Swimming Training and Crocin Consumption on Intrinsic Apoptosis Pathway in Muscle Tissue of High-Fat Diet-induced Obese Rats. Middle East J Rehabil Health Stud. 2019;In Press(In Press) [Crossref]

14- Sadigi B, Yarani R, Mirghafourvand M, Travica N, Yousefi Z, Shakouri S, Ostadrahimi A, Mobasseri M, Pociot F, Sanaie S, Araj‐Khodaei M. The effect of saffron supplementation on glycemic parameters: An overview of systematic reviews. Phytotherapy Research. 2022;36(9):3444 [Crossref]

15- Davari F, Alimanesh Z, Alimanesh Z, Salehi O, Hosseini S. Effect of training and crocin supplementation on mitochondrial biogenesis and redox-sensitive transcription factors in liver tissue of type 2 diabetic rats. Archives of Physiology and Biochemistry. 2022;128(5):1215 [Crossref]

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