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Pharm Sci. 2018;24(2): 104-111. doi: 10.15171/PS.2018.16

Research Article

Effects of Carob (Ceratonia siliqua) on Sperm Quality, Testicular Structure, Testosterone Level and Oxidative Stress in Busulfan-Induced Infertile Mice

Azadeh Vafaei 1, Shabnam Mohammadi 2 * , Alireza Fazel 1, Mohammad Soukhtanloo 3, Abbas Mohammadipour 1, Farimah Beheshti 4

Cited by CrossRef: 27

1- sadat S, mohammadi S, fazel A, sazegar G, ebrahimzadeh A, Ghayour Mobarhan M, Boroumand-Noughabi S. Hepatotoxicity and Nephrotoxicity Evaluation of Carob Extract (Ceratonia siliqua) in Balb/C Mice. J Med Plants. 2020;4(72):267 [Crossref]
2- Ebrahimpour N, Khazaneha M, Mehrbani M, Rayegan P, Raeiszadeh M. Efficacy of Herbal Based Syrup on male sexual experiences: A double-blind randomized clinical trial. Journal of Traditional and Complementary Medicine. 2021;11(2):103 [Crossref]
3- Sadat S, Mohammadi S, Sazegar G, Fazel A, Ebrahimzadeh A, Ghayour Mobarhan M, Beheshti F, Attari S, Tavallaei S. Effects of Carob Fruit Extract on Spermatogenesis, Antioxidant Status, and Apoptosis in Adult Male Mice. Pharm Sci. 2019;25(3):184 [Crossref]
4- Salahshoor M, Abdolmaleki A, Faramarzi A, Ziapour A, Roshankhah S. Thymus vulgaris attenuates myleran-induced reproductive damage by decreasing oxidative stress and lipid peroxidation in male rats. J Hum Reprod Sci. 2020;13(1):38 [Crossref]
5- Roshankhah S, Abdolmaleki A, Jalili C, Salahshoor M. Crocin Reduces Oxidative Stress Produced by Busulfan Administration on Fertility of Male Rats. J Adv Med Biomed Res. 2019;27(125):25 [Crossref]
6- Nemati Z, Dehgani P, Besharati M, Amirdahri S. Dietary carob fruit (Ceratonia siliqua L.) supplementation improves spermatogenesis, semen quality and embryonic death via antioxidant effect in aging broiler breeder roosters. Animal Reproduction Science. 2022;239:106967 [Crossref]
7- Javanmard F, Bidmeshkipour A, Ghasemian Yadegari J. Ceratonia siliqua L improved cryodamage of asthenozoospermic specimens: An experimental study. IJRM. 2023;20(12):1029 [Crossref]
8- Ali E, Tayel S, Abbas M. Sitagliptin ameliorates busulfan-induced pulmonary and testicular injury in rats through antioxidant, anti-inflammatory, antifibrotic, and antiapoptotic effects. Sci Rep. 2023;13(1) [Crossref]
9- Oyovwi M, Ben-Azu B, Edesiri T, Victor E, Rotu R, Ozegbe Q, Nwangwa E, Atuadu V, Adebayo O. Kolaviron abates busulfan-induced episodic memory deficit and testicular dysfunction in rats: The implications for neuroendopathobiological changes during chemotherapy. Biomedicine & Pharmacotherapy. 2021;142:112022 [Crossref]
10- Aghajani M, Mahjoub S, Mojab F, Namdari M, Gorji N, Dashtaki A, Mirabi P. Comparison of the Effect of Ceratonia siliqua L. (Carob) Syrup and Vitamin E on Sperm Parameters, Oxidative Stress Index, and Sex Hormones in Infertile Men: a Randomized Controlled Trial. Reprod Sci. 2021;28(3):766 [Crossref]
11- Saraç H, Özpınar H. The Effect of Nettle (Urtica dioica L.), Carob (Ceratonia siliqua L.), and Chaste (Vitex agnus-castus L.) Plants on Fertility in Caenorhabditis elegans. 2024; [Crossref]
12- Sanagoo S, Farshbaf-Khalili A, Asgharian P, Hazhir S, Oskouei B. Comparison of the effect of Ceratonia siliqua L. fruit oral capsule and vitamin E on semen parameters in men with idiopathic infertility: a triple-blind randomized controlled clinical trial. 2021;18(4):791 [Crossref]
13- Basharat Z, Afzaal M, Saeed F, Islam F, Hussain M, Ikram A, Pervaiz M, Awuchi C. Nutritional and functional profile of carob bean ( Ceratonia siliqua ): a comprehensive review . International Journal of Food Properties. 2023;26(1):389 [Crossref]
14- Oztekin U, Caniklioglu M, Firat F, Atac F, Doganyigit Z, Gocmen A, Yilmaz S, Tokpinar A. Carob attenuates nicotine‐induced oxidative stress and intratesticular damage in male rats. Andrologia. 2020;52(9) [Crossref]
15- Faramarzi A, Aghaz F, Bakhtiari M, Khazaei M. In vitro application of Ceratonia siliqua improved sperm parameters and chromatin quality after vitrifacation in normozoospermic aged men. Middle East Fertil Soc J. 2020;24(1) [Crossref]
16- Ansari M. Recent strategies to mitigate reproductive aging in male broiler breeders: A review. Animal Reproduction Science. 2024;268:107570 [Crossref]
17- Ghorbaninejad Z, Eghbali A, Ghorbaninejad M, Ayyari M, Zuchowski J, Kowalczyk M, Baharvand H, Shahverdi A, Eftekhari-Yazdi P, Esfandiari F. Carob Extract Induces Spermatogenesis in an Infertile Mouse Model Via Upregulation of Genes Involved in Spermatogenesis. SSRN Journal. 2021; [Crossref]
18- Farazmand T, Mansouri F, Koohestanidehaghi Y, Shahandeh E. Human sperm parameter improvement associated with Ceratonia siliqua extract as a cryopreservation supplement after vitrification. Clin Exp Reprod Med. 2023;50(2):86 [Crossref]
19- Jalilvand N, Hosseini M, Beheshti F, Ebrahimzadeh-Bideskan A. Protective effect of PPARγ agonist pioglitazone, on testicular tissue and sperm parameters in hypothyroid rats. Toxin Reviews. 2021;40(3):267 [Crossref]
20- Firouzabadi A. Ceratonia Siliqua L: A Natural Compound with Big Impact on Male Reproductive System. Am J Mens Health. 2024;18(5) [Crossref]
21- Norasteh H, Mohammadi S, Nikravesh M, Broumand S, Beheshti F. Effects of Bene (Pistacia atlantica) on Histopathology of Testis, Sperm Chromatin Quality and Stress Oxidative in Busulfan-Induced Infertile Mice. Pharm Sci. 2019;25(1):24 [Crossref]
22- Yardim Ş, Dursun M, Sözmen İ, Aydin A, Kadioğlu A, Uslu Ü, Demirci E. Ceratonia siliqua Protects Testicular Tissue in Ischemia/Reperfusion Injury. Int J of Urology. 2025; [Crossref]
23- Faramarzi A, Aghaz F, Golestan Jahromi M, Bakhtiari M, Khazaei M. Does supplementation of sperm freezing/thawing media with Ceratonia siliqua improve detrimental effect of cryopreservation on sperm parameters and chromatin quality in normozoospermic specimens?. Cell Tissue Bank. 2019;20(3):403 [Crossref]
24- MehdiKhani H, Shariati M, Forouzanfar M, Ebrahim Hosseini S. Protective effects of Ceratonia siliqua extract on protamine gene expression, testicular function, and testicular histology in doxorubicin-treated adult rats: An experimental study. IJRM. 2020;18(8):667 [Crossref]
25- Mehraban Z, Gaffari Novin M, Golmohammadi M, Nazarian H. Effect of Ceratonia siliqua L. extract on DNA Fragmentation of Sperm in Adult Male Mice Treated with Cyclophosphamide. Reprod Sci. 2021;28(4):974 [Crossref]
26- Abolghasemi M, Aghajani M, Mojab F, Gorji N, Zakariayi S, Mirabi P. Carob effects on antioxidant enzyme and elements level in infertile men: Secondary data analysis from a randomized controlled trial. Journal of Herbal Medicine. 2022;36:100596 [Crossref]
27- Sadeghzadeh F, Sadeghzadeh A, Changizi-Ashtiyani S, Bakhshi S, Jalali Mashayekhi F, Mashayekhi M, Poorcheraghi H, Zarei A, Jafari M. The effect of hydro-alcoholic extract of Ceratonia Silique L. on spermatogenesis index in rats treated with cyclophosphamide: An experimental study. IJRM. 2020;18(4):295 [Crossref]

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