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Pharm Sci. 2019;25(1): 1-10. doi: 10.15171/PS.2019.1

Research Article

Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity

Reza Heidari 1 * ORCID, Mohammad Reza Arabnezhad 2, Mohammad Mehdi Ommati 2, Negar Azarpira 3, Elham Ghodsimanesh 2, Hossein Niknahad 1,2 * ORCID

Cited by CrossRef: 22

1- Ommati M, Sabouri S, Retana-Marquez S, Nategh Ahmadi H, Arjmand A, Alidaee S, Mazloomi S, Akhlagh A, Abdoli N, Niknahad H, Jamshidzadeh A, Ma Y, Azarpira N, Asefi Y, Heidari R. Taurine Improves Sperm Mitochondrial Indices, Blunts Oxidative Stress Parameters, and Enhances Steroidogenesis and Kinematics of Sperm in Lead-Exposed Mice. Reprod Sci. 2023;30(6):1891 [Crossref]
2- Silva L, de Souza G, Pateis V, Ames-Sibin A, Silva B, Bracht L, Comar J, Peralta R, Bracht A, Sá-Nakanishi A, Fortofoiu M. Inhibition of Gluconeogenesis by Boldine in the Perfused Liver: Therapeutical Implication for Glycemic Control. International Journal of Hepatology. 2023;2023:1 [Crossref]
3- Ommati M, Farshad O, Azarpira N, Ghazanfari E, Niknahad H, Heidari R. Silymarin mitigates bile duct obstruction-induced cholemic nephropathy. Naunyn-Schmiedeberg's Arch Pharmacol. 2021;394(6):1301 [Crossref]
4- Ommati M, Farshad O, Jamshidzadeh A, Heidari R. Taurine enhances skeletal muscle mitochondrial function in a rat model of resistance training. PharmaNutrition. 2019;9:100161 [Crossref]
5- Ommati M, Mohammadi H, Mousavi K, Azarpira N, Farshad O, Dehghani R, Najibi A, Kamran S, Niknahad H, Heidari R. Metformin alleviates cholestasis-associated nephropathy through regulating oxidative stress and mitochondrial function. Liver Research. 2021;5(3):171 [Crossref]
6- jafari S, fathi M, Rahmati M. Effects of Taurine Supplementation during Endurance Training on Antioxidant Activity in Males. mljgoums. 2023;17(3):38 [Crossref]
7- Patel J, Roy H, Chintamaneni P, Patel R, Bohara R. Advanced Strategies in Enhancing the Hepatoprotective Efficacy of Natural Products: Integrating Nanotechnology, Genomics, and Mechanistic Insights. ACS Biomater Sci Eng. 2025; [Crossref]
8- Toledo J, Fernández-Pérez E, Ferreira I, Marinho D, Riffo-Lepe N, Pineda-Cuevas B, Pinochet-Pino L, Burgos C, Rego A, Aguayo L. Boldine Attenuates Synaptic Failure and Mitochondrial Deregulation in Cellular Models of Alzheimer’s Disease. Front Neurosci. 2021;15 [Crossref]
9- Ommati M, Jin Y, Zamiri M, Retana-Marquez S, Nategh Ahmadi H, Sabouri S, Song S, Heidari R, Wang H. Sex-Specific Mechanisms of Fluoride-Induced Gonadal Injury: A Multi-Omics Investigation into Reproductive Toxicity and Gut Microbiota Disruption. J Agric Food Chem. 2025;73(4):2527 [Crossref]
10- Fouad D, Shuker E, Farhood M. Renal toxicity of methylprednisolone in male Wistar rats and the potential protective effect by boldine supplementation. Journal of King Saud University - Science. 2023;35(1):102381 [Crossref]
11- Najafi H, Abolmaali S, Heidari R, Valizadeh H, Tamaddon A, Azarpira N. Integrin receptor-binding nanofibrous peptide hydrogel for combined mesenchymal stem cell therapy and nitric oxide delivery in renal ischemia/reperfusion injury. Stem Cell Res Ther. 2022;13(1) [Crossref]
12- Ommati M, Farshad O, Mousavi K, Khalili M, Jamshidzadeh A, Heidari R. Chlorogenic acid supplementation improves skeletal muscle mitochondrial function in a rat model of resistance training. Biologia. 2020;75(8):1221 [Crossref]
13- Abdoli N, Sadeghian I, Mousavi K, Azarpira N, Ommati M, Heidari R. Suppression of cirrhosis-related renal injury by N-acetyl cysteine. Current Research in Pharmacology and Drug Discovery. 2020;1:30 [Crossref]
14- Ommati M, Sabouri S, Niknahad H, Arjmand A, Alidaee S, Mazloomi S, Najibi A, Rezaei H, Ghiasvand A, Ahmadi P, Nikoozadeh A, Khodaei F, Abdoli N, Azarpira N, Heidari R. Pulmonary inflammation, oxidative stress, and fibrosis in a mouse model of cholestasis: the potential protective properties of the dipeptide carnosine. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(6):1129 [Crossref]
15- Jiang D, Xu Y, Han X, Yang L, Li Q, Yang Y, Wang Y, Guo A, Li H, Fan Z, Chao L. Cresyl Diphenyl Phosphate exposure induces reproductive functional defects in men and male mice. Ecotoxicology and Environmental Safety. 2024;271:116003 [Crossref]
16- Ezhilarasan D, Raghunandhakumar S. Boldine treatment protects acetaminophen‐induced liver inflammation and acute hepatic necrosis in mice. J Biochem & Molecular Tox. 2021;35(4) [Crossref]
17- HACER TURGUT N, GUNGOR H, EKICI M, ALPER ERDOGAN M, ONDER KARAYIGIT M, KARA H. Boldine provides protective effect against nephrotoxicity induced by cisplatin in Wistar rats: Role of oxidative stress, inflammation and caspase-3. 2022;46(9):2111 [Crossref]

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