Antimalarial Drugs-Induced Hepatic Injury in Rats and the Protective Role of Carnosine

Akram Jamshidzadeh ^1,2, Reza Heidari ¹ * , Farzaneh Abazari ², Maral Ramezani ², Forouzan Khodaei ², Mohammad Mehdi Ommati ³, Maryam Ayarzadeh ², Roya Firuzi ², Arastoo Saeedi ², Negar Azarpira ⁴, Asma Najibi ²

Cited by CrossRef: 13

1- Ommati M, Mobasheri A, Heidari R. Drug‐induced organ injury in coronavirus disease 2019 pharmacotherapy: Mechanisms and challenges in differential diagnosis and potential protective strategies. J Biochem & Molecular Tox. 2021;35(7) [Crossref]

2- Brito C, Barros F, Lopes E. Mechanisms and consequences of COVID-19 associated liver injury: What can we affirm?. WJH. 2020;12(8):413 [Crossref]

3- Jamshidzadeh A, Niknahad H, Heidari R, Azadbakht M, Khodaei F, Arabnezhad M, Farshad O. Propylthiouracil-induced mitochondrial dysfunction in liver and its relevance to drug-induced hepatotoxicity. Pharm Sci. 2017;23(2):95 [Crossref]

4- Yun S, Kim J, Back M, Kim H, Ha H, Jang J, Kim D. Comparison of three human liver cell lines for in vitro drug-induced liver injury assessment: Huh7, HepaRG, and stem cell-derived hepatocytes. Mol Cell Toxicol. 2019;15(3):271 [Crossref]

5- Compaoré Y, Zongo I, Somé A, Barry N, Nikiéma F, Kaboré T, Ouattara A, Kabré Z, Wermi K, Zongo M, Yerbanga R, Sagara I, Djimdé A, Ouédraogo J. Hepatic safety of repeated treatment with pyronaridine‐artesunate versus artemether–lumefantrine in patients with uncomplicated malaria: a secondary analysis of the WANECAM 1 data from Bobo-Dioulasso, Burkina Faso. Malar J. 2021;20(1) [Crossref]

6- Ommati M, Heidari R, Zamiri M, Sabouri S, Zaker L, Farshad O, Jamshidzadeh A, Mousapour S. The Footprints of Oxidative Stress and Mitochondrial Impairment in Arsenic Trioxide-Induced Testosterone Release Suppression in Pubertal and Mature F1-Male Balb/c Mice via the Downregulation of 3β-HSD, 17β-HSD, and CYP11a Expression. Biol Trace Elem Res. 2020;195(1):125 [Crossref]

7- Eftekhari A, Heidari R, Ahmadian E, Eghbal M. Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes. Pharm Sci. 2018;24(4):257 [Crossref]

8- Falcão M, Pamplona de Góes Cavalcanti L, Filgueiras Filho N, Antunes de Brito C. Case Report: Hepatotoxicity Associated with the Use of Hydroxychloroquine in a Patient with COVID-19. 2020;102(6):1214 [Crossref]

9- Adikwu E, Bokolo B, Odeghe O. Ethanolic Leaf Extract of Ocimum gratissimum Abrogates Methotrexate-induced Liver Injury in Albino Rats. Asian J of Biological Sciences. 2020;13(2):201 [Crossref]

10- Ommati M, Heidari R, Ghanbarinejad V, Aminian A, Abdoli N, Niknahad H. The neuroprotective properties of carnosine in a mouse model of manganism is mediated via mitochondria regulating and antioxidative mechanisms. Nutritional Neuroscience. 2020;23(9):731 [Crossref]

11- Junior D, Lacerda P, de Pilla Varotti F, Leite F. Towards development of new antimalarial compounds through in silico and in vitro assays. Computational Biology and Chemistry. 2024;111:108093 [Crossref]

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