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Pharm Sci. 2015;21(2): 94-101. doi: 10.15171/PS.2015.23

Original Research

Propylthiouracil-Induced Liver Injury in Mice and the Protective Role of Taurine

Raziyeh Karamikhah 1,2, Akram Jamshidzadeh 1,2, Negar Azarpira 3, Arastoo Saeidi 2, Reza Heidari 1,4 *

Cited by CrossRef: 13


1- Ommati M, Ahmadi H, Sabouri S, Retana‐Marquez S, Abdoli N, Rashno S, Niknahad H, Jamshidzadeh A, Mousavi K, Rezaei M, Akhlagh A, Azarpira N, Khodaei F, Heidari R. Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downregulation of enzymes involved in the steroidogenesis. Environmental Toxicology. 2022;37(12):2990 [Crossref]
2- Farshad O, Keshavarz P, Heidari R, Farahmandnejad M, Azhdari S, Jamshidzadeh A.

The Potential Neuroprotective Role of Citicoline in Hepatic Encephalopathy

. JEP. 2020;Volume 12:517 [Crossref]
3- Ommati M, Mobasheri A, Niknahad H, Rezaei M, Alidaee S, Arjmand A, Mazloomi S, Abdoli N, Sadeghian I, Sabouri S, Saeed M, Mousavi K, Najibi A, Heidari R. Low‐dose ketamine improves animals' locomotor activity and decreases brain oxidative stress and inflammation in ammonia‐induced neurotoxicity. J Biochem & Molecular Tox. 2023;37(11) [Crossref]
4- Khodayar M, Kalantari H, Khorsandi L, Ahangar N, Samimi A, Alidadi H. Taurine attenuates valproic acid-induced hepatotoxicity via modulation of RIPK1/RIPK3/MLKL-mediated necroptosis signaling in mice. Mol Biol Rep. 2021;48(5):4153 [Crossref]
5- Ommati M, Mobasheri A, Ma Y, Xu D, Tang Z, Manthari R, Abdoli N, Azarpira N, Lu Y, Sadeghian I, Mousavifaraz A, Nadgaran A, Nikoozadeh A, Mazloomi S, Mehrabani P, Rezaei M, Xin H, Mingyu Y, Niknahad H, Heidari R. Taurine mitigates the development of pulmonary inflammation, oxidative stress, and histopathological alterations in a rat model of bile duct ligation. Naunyn-Schmiedeberg's Arch Pharmacol. 2022;395(12):1557 [Crossref]
6- Ommati M, Sabouri S, Retana-Marquez S, Nategh Ahmadi H, Arjmand A, Alidaee S, Mazloomi S, Akhlagh A, Abdoli N, Niknahad H, Jamshidzadeh A, Ma Y, Azarpira N, Asefi Y, Heidari R. Taurine Improves Sperm Mitochondrial Indices, Blunts Oxidative Stress Parameters, and Enhances Steroidogenesis and Kinematics of Sperm in Lead-Exposed Mice. Reprod Sci. 2023;30(6):1891 [Crossref]
7- Jamshidzadeh A, Niknahad H, Heidari R, Azadbakht M, Khodaei F, Arabnezhad M, Farshad O. Propylthiouracil-induced mitochondrial dysfunction in liver and its relevance to drug-induced hepatotoxicity. Pharm Sci. 2017;23(2):95 [Crossref]
8- Heidari R, Behnamrad S, Khodami Z, Ommati M, Azarpira N, Vazin A. The nephroprotective properties of taurine in colistin-treated mice is mediated through the regulation of mitochondrial function and mitigation of oxidative stress. Biomedicine & Pharmacotherapy. 2019;109:103 [Crossref]
9- Heidari R, Ahmadi F, Rahimi H, Azarpira N, Hosseinzadeh M, Najibi A, Niknahad H. Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice. Drug and Chemical Toxicology. 2019;42(6):615 [Crossref]
10- Ommati M, Rezaei H, Socorro R, Tian W, Zhao J, Rouhani A, Sabouri S, Ghaderi F, Niknahad A, Najibi A, Mazloomi S, Safipour M, Honarpishefard Z, Wang H, Niknahad H, Heidari R. Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity. Life Sciences. 2024;336:122284 [Crossref]