Pharm Sci. 2018;24(2): 141-147.
doi: 10.15171/PS.2018.21

Scopus ID: 85049327525
  Abstract View: 641
  PDF Download: 843

Research Article

Quality Control of the Migration of Bisphenol a from Plastic Packaging into Iranian Brands of Food Grade Oils

Mahboob Nemati 1,2, Sara Nofozi 3, Shirin Ahmadi 4, Farnaz Monajjemzadeh 1,2,5 *

1 Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Pharmaceutical and Food Control, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Student Research Committee, Tabriz University of Medical sciences, Tabriz, Iran.
4 Central lab, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.


Background: Bis-phenol A (BPA) can migrate into food stuff from packaging materials and accounts for food contamination. This research was designed to measure BPA contamination in the Iranian brands of food grade oils and to find out the possible effect of production date on the amount of BPA migration. Methods: Ten well-known and top selling oils packed in various containers, were selected and sampled according to their batch number and production date stated on the label. Subsequently, BPA was extracted by reverse phase dispersive liquid-liquid extraction (RP-DLLME) method and quantified by HPLC. Results: The measured quantity of BPA in the food grade oil was ranged between 0.5 to 4.37 µg/g of oil samples regardless of the date of production, the Batch Number, and the producing company. Statistical analysis revealed that the difference of BPA content in oil samples did not depend on their production date. Conclusion: According to the amount of allowable migration introduced by European committee, the amount of BPA migration and consequently contamination of almost all tested samples exceeds SML. Considering the toxic effects reported especially in fetus and young children, prompt regulatory interference is needed in this area.
Keywords: Bisphenol A, Contamination, RP-DLLME, HPLC, Food grade oil, Sampling Procedure
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Submitted: 21 Aug 2017
Revision: 26 Aug 2017
Accepted: 08 Oct 2017
ePublished: 20 Jun 2018
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