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Pharm Sci. 2023;29(2): 208-218. doi: 10.34172/PS.2022.34

Research Article

Preparation and In-Vitro Evaluation of Ketoconazole-Loaded Niosome (Ketosome) for Drug Delivery to Cutaneous Candidiasis

Katayoun Morteza-Semnani 1 ORCID, Majid Saeedi 2,3 ORCID, Jafar Akbari 3, Maryam Moazeni 4,5, Amirhossein Babaei 3,6 ORCID, Reza Negarandeh 3,6, Maedeh Azizi 6, Mohammad Eghbali 2,3, Seyyed Mohammad Hassan Hashemi 7 * ORCID

Cited by CrossRef: 3

1- Nayak D, Shetty M, Halagali P, Rathnanand M, Gopinathan A, John J, Krishna Tippavajhala V. Formulation, optimization and evaluation of ibuprofen loaded menthosomes for transdermal delivery. International Journal of Pharmaceutics. 2024;665:124671 [Crossref]
2- Norozipuor S, Agha Kuchak Afshari S. The efficacy of niosomal antifungal drug delivery system for Candida infections: a literature review. 2025;36(3):184 [Crossref]
3- Tiwari T, Kaul S, Nagaich U, Pandey M, Mishra D, Jain N. In Vitro Toxicity, Safety, and Skin Permeability Evaluation of Antifungal Transferosomal Hydrogels for the Advanced Management of Foot Dermatophytosis. BioNanoSci. 2025;15(3) [Crossref]
4- Pirojiya H, Dudhat K. Niosomes: A Revolution in Sustainable and Targeted Drug Delivery-Green Synthesis, Precision Medicine, and Beyond. Regen Eng Transl Med. 2025;11(2):379 [Crossref]
5- Nosair A, Abdelaziz A, Abo-Kamar A, Al-Madboly L, Farghali M. Deciphering the efficacy of staphyloxanthin-encapsulated niosomal nanovesicles to attenuate biofilm formation, quorum sensing, and meropenem persistence in Acinetobacter baumannii. BMC Microbiol. 2025;25(1) [Crossref]
6- Hamed R, Alkilani A, Al-Adhami Y, Musleh B, Aburayya R. Advances in transdermal delivery systems for Antifungals: Current approaches and future perspectives. Microbial Pathogenesis. 2025;206:107776 [Crossref]
7- Sabale V, Ingole A, More S, Sabale P. Formulation, Optimization and Pharmacokinetic Evaluation of Mangiferin-loaded Niosomes for Enhanced Breast Cancer Activity. J Pharm Innov. 2026;21(1) [Crossref]
8- Salehi M, Haghani I, Saeedi M, Morteza-Semnani K, Negarandeh R, Hosseinnataj A, Jafari A, Lotfizadeh A, Rafiei A, Molania T. Antifungal efficacy of caffeic acid and nano-caffeic acid particles against candidiasis: an in vitro study . Journal of Oral Microbiology. 2025;17(1) [Crossref]
9- Saeedi M, Morteza-Semnani K, Akbari J, Rahimnia S, Ahmadi F, Choubdari H, Lotfi A, Hashemi S. Development of kojic acid loaded collagen-chitosan nanoparticle as skin lightener product: in vitro and in vivo assessment. Journal of Biomaterials Science, Polymer Edition. 2024;35(1):63 [Crossref]
10- Haghani I, Raeisabadi A, Akhtari J, Arbabi A, Abastabar M, Hedayati M, Yahyazadeh Z, Talebpour Amiri F, Hashemi S, Davoodi L, Nezhad Y, Siahposht-Khachaki A, Bandegani A, Rahimnia S, Badali H. Innovative green niosomal piperlongumine as a novel topical treatment for dermatophytosis in guinea pigs model. Sci Rep. 2025;15(1) [Crossref]
11- Sheikhaghaei Z, Shayanfar A. Crystal engineering to improve the physicochemical properties of ketoconazole in the presence of saccharin. Results in Chemistry. 2026;19:102919 [Crossref]
12- Sheikhhosseini M, Soltanian S, Mohamadi N. Co-delivery of doxorubicin and piperine using niosomes exhibited enhanced cytotoxic and inhibitory effect on cancer stem cell markers in breast cancer cells. Pharmaceutical Development and Technology. 2025;30(7):1015 [Crossref]
13- Devi K, Agarwal S, Kumari R, Saini V. Overcoming the Challenges in Topical Delivery of Antifungal Agents for Skin Fungal Infections. CDTH. 2025;20(7):1019 [Crossref]
14- Abadi S, Peyvandi K, Shariat S. Investigation of the preparation of iron sulfate-loaded niosomes by an experimental novel method. Sci Rep. 2025;15(1) [Crossref]

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