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Pharm Sci. 2022;28(1): 76-85. doi: 10.34172/PS.2021.22

Research Article

Concanavalin-A Shows Synergistic Cytotoxicity with Tamoxifen via Inducing Apoptosis in Estrogen Receptor-Positive Breast Cancer: In Vitro and Molecular Docking Studies

Mohamed Elshal 1 ORCID, Norhan Eid 1, Ibrahim El-Sayed 2, Wael El-Sayed 3, Ahmed Ali Al-Karmalawy 4 * ORCID

Cited by CrossRef: 14

1- DEMİRCİ S, AYHAN F. PEG-DA/Concanavalin A Biocomposite Hydrogels Synthesis And Investigations For Cancer Therapy. EJOSAT. 2022; [Crossref]
2- Kandeil A, Mostafa A, Kutkat O, Moatasim Y, Al-Karmalawy A, Rashad A, Kayed A, Kayed A, El-Shesheny R, Kayali G, Ali M. Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2. Pathogens. 2021;10(6):758 [Crossref]
3- Ibrahim R, El-Shiekh R, Mohamed O, Al-Karmalawy A, Tripathi A, Abdel-Baki P. LC/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies. Plant Foods Hum Nutr. 2024;79(2):359 [Crossref]
4- Shahid I, Shoaib M, Raza R, Jahangir M, Abbasi S, Riasat A, Akbar A, Mehnaz S. In-silico Evaluation of Novel Honokiol Derivatives against Breast Cancer Target Protein LKB1. ACAMC. 2023;23(12):1388 [Crossref]
5- Hammouda M, Elmaaty A, Nafie M, Abdel-Motaal M, Mohamed N, Tantawy M, Belal A, Alnajjar R, Eldehna W, Al‐Karmalawy A. Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies. Bioorganic Chemistry. 2022;127:105995 [Crossref]
6- Elebeedy D, Ghanem A, El-Sayed M, Fayad E, Abu Ali O, Alyamani A, Sayed Abdelgeliel A. Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus. IDR. 2022;Volume 15:545 [Crossref]
7- Pallar R, Pingle S, Gaikwad A, Yennam N, Raju N, Kumar P, Adepu V, Tumane R, Veeranjaneyulu C, Matte K. Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers. Mol Biotechnol. 2025;67(2):456 [Crossref]
8- Al-Karmalawy A, Nafie M, Shaldam M, Elmaaty A, Antar S, El-Hamaky A, Saleh M, Elkamhawy A, Tawfik H. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. J Med Chem. 2023;66(1):777 [Crossref]
9- Elmaaty A, Darwish K, Chrouda A, Boseila A, Tantawy M, Elhady S, Shaik A, Mustafa M, Al-karmalawy A. In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity. ACS Omega. 2022;7(1):875 [Crossref]
10- Shalaby A, Eid H, El-Shiekh R, Mohamed O, Tripathi A, Al-Karmalawy A, Sleem A, Morsy F, Ibrahim K, Tadros S, Youssef F. Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity. ACS Omega. 2023;8(29):26444 [Crossref]
11- Diab R, Abdel-Sami Z, Abdel-Aal E, Al-Karmalawy A, Abo-Dya N. Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies. New J Chem. 2021;45(46):21657 [Crossref]
12- Ezz Eldin R, Al-Karmalawy A, Alotaibi M, Saleh M. Quinoxaline derivatives as a promising scaffold for breast cancer treatment. New J Chem. 2022;46(21):9975 [Crossref]
13- El-Demerdash A, Al-Karmalawy A, Abdel-Aziz T, Elhady S, Darwish K, Hassan A. Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors. RSC Adv. 2021;11(50):31339 [Crossref]
14- El-Naggar A, Hassan A, Elkaeed E, Alesawy M, Al‐Karmalawy A. Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2. Bioorganic Chemistry. 2022;123:105770 [Crossref]

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