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Pharm Sci. 2022;28(1): 76-85. doi: 10.34172/PS.2021.22

Research Article

Concanavalin-A Shows Synergistic Cytotoxicity with Tamoxifen via Inducing Apoptosis in Estrogen Receptor-Positive Breast Cancer: In Vitro and Molecular Docking Studies

Mohamed Elshal 1 ORCID, Norhan Eid 1, Ibrahim El-Sayed 2, Wael El-Sayed 3, Ahmed Ali Al-Karmalawy 4 * ORCID

Cited by CrossRef: 17

1- Gharib A, Alaa Eldeen M, Khalifa A, Elsawy W, Eed E, Askary A, Eid R, Soltan M, Raafat N. Assessment of Glutathione Peroxidase-1 (GPX1) Gene Expression as a Specific Diagnostic and Prognostic Biomarker in Malignant Pleural Mesothelioma. Diagnostics. 2021;11(12):2285 [Crossref]
2- DEMİRCİ S, AYHAN F. PEG-DA/Concanavalin A Biocomposite Hydrogels Synthesis And Investigations For Cancer Therapy. EJOSAT. 2022; [Crossref]
3- Ibrahim R, El-Shiekh R, Mohamed O, Al-Karmalawy A, Tripathi A, Abdel-Baki P. LC/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies. Plant Foods Hum Nutr. 2024; [Crossref]
4- Shahid I, Shoaib M, Raza R, Jahangir M, Abbasi S, Riasat A, Akbar A, Mehnaz S. In-silico Evaluation of Novel Honokiol Derivatives against Breast Cancer Target Protein LKB1. ACAMC. 2023;23(12):1388 [Crossref]
5- Hammouda M, Elmaaty A, Nafie M, Abdel-Motaal M, Mohamed N, Tantawy M, Belal A, Alnajjar R, Eldehna W, Al‐Karmalawy A. Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies. Bioorganic Chemistry. 2022;127:105995 [Crossref]
6- Elebeedy D, Ghanem A, El-Sayed M, Fayad E, Abu Ali O, Alyamani A, Sayed Abdelgeliel A. Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus. IDR. 2022;Volume 15:545 [Crossref]
7- Pallar R, Pingle S, Gaikwad A, Yennam N, Raju N, Kumar P, Adepu V, Tumane R, Veeranjaneyulu C, Matte K. Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers. Mol Biotechnol. 2024; [Crossref]
8- Al-Karmalawy A, Nafie M, Shaldam M, Elmaaty A, Antar S, El-Hamaky A, Saleh M, Elkamhawy A, Tawfik H. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. J Med Chem. 2023;66(1):777 [Crossref]
9- Al-Karmalawy A, Farid M, Mostafa A, Ragheb A, H. Mahmoud S, Shehata M, Shama N, GabAllah M, Mostafa-Hedeab G, Marzouk M. Naturally Available Flavonoid Aglycones as Potential Antiviral Drug Candidates against SARS-CoV-2. Molecules. 2021;26(21):6559 [Crossref]
10- Salem M, Aborehab N, Al-Karmalawy A, Fernie A, Alseekh S, Ezzat S. Potential Valorization of Edible Nuts By-Products: Exploring the Immune-Modulatory and Antioxidants Effects of Selected Nut Shells Extracts in Relation to Their Metabolic Profiles. Antioxidants. 2022;11(3):462 [Crossref]
11- Elmaaty A, Darwish K, Chrouda A, Boseila A, Tantawy M, Elhady S, Shaik A, Mustafa M, Al-karmalawy A. In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity. ACS Omega. 2022;7(1):875 [Crossref]
12- Roshdy W, Kandeil A, El-Shesheny R, Khalifa M, Al-Karmalawy A, Showky S, Naguib A, Elguindy N, Fahim M, Abu Elsood H, El Taweel A, Salamony A, Mohsen A, Kayali G, Ali M, Kandeel A. Insight into Genetic Characteristics of Identified SARS-CoV-2 Variants in Egypt from March 2020 to May 2021. Pathogens. 2022;11(8):834 [Crossref]
13- Shalaby A, Eid H, El-Shiekh R, Mohamed O, Tripathi A, Al-Karmalawy A, Sleem A, Morsy F, Ibrahim K, Tadros S, Youssef F. Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity. ACS Omega. 2023;8(29):26444 [Crossref]
14- Diab R, Abdel-Sami Z, Abdel-Aal E, Al-Karmalawy A, Abo-Dya N. Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies. New J Chem. 2021;45(46):21657 [Crossref]
15- Ezz Eldin R, Al-Karmalawy A, Alotaibi M, Saleh M. Quinoxaline derivatives as a promising scaffold for breast cancer treatment. New J Chem. 2022;46(21):9975 [Crossref]
16- El-Demerdash A, Al-Karmalawy A, Abdel-Aziz T, Elhady S, Darwish K, Hassan A. Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors. RSC Adv. 2021;11(50):31339 [Crossref]
17- El-Naggar A, Hassan A, Elkaeed E, Alesawy M, Al‐Karmalawy A. Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2. Bioorganic Chemistry. 2022;123:105770 [Crossref]
18- Al-Karmalawy A, Soltane R, Abo Elmaaty A, Tantawy M, Antar S, Yahya G, Chrouda A, Pashameah R, Mustafa M, Abu Mraheil M, Mostafa A. Coronavirus Disease (COVID-19) Control between Drug Repurposing and Vaccination: A Comprehensive Overview. Vaccines. 2021;9(11):1317 [Crossref]

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