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Pharm Sci. 2022;28(1): 76-85. doi: 10.34172/PS.2021.22

Research Article

Concanavalin-A Shows Synergistic Cytotoxicity with Tamoxifen via Inducing Apoptosis in Estrogen Receptor-Positive Breast Cancer: In Vitro and Molecular Docking Studies

Mohamed Elshal 1 ORCID, Norhan Eid 1, Ibrahim El-Sayed 2, Wael El-Sayed 3, Ahmed Ali Al-Karmalawy 4 * ORCID

Cited by CrossRef: 14

1- Chfat H, Radhi A, Radhi A, Alrubaie I. Design, synthesis, In Silico and in vitro studies urea derivatives as VEGFR-2 inhibitors. Journal of Molecular Structure. 2025;1343:142863 [Crossref]
2- DEMİRCİ S, AYHAN F. PEG-DA/Concanavalin A Biocomposite Hydrogels Synthesis And Investigations For Cancer Therapy. EJOSAT. 2022; [Crossref]
3- Kandeil A, Mostafa A, Kutkat O, Moatasim Y, Al-Karmalawy A, Rashad A, Kayed A, Kayed A, El-Shesheny R, Kayali G, Ali M. Bioactive Polyphenolic Compounds Showing Strong Antiviral Activities against Severe Acute Respiratory Syndrome Coronavirus 2. Pathogens. 2021;10(6):758 [Crossref]
4- Ibrahim R, El-Shiekh R, Mohamed O, Al-Karmalawy A, Tripathi A, Abdel-Baki P. LC/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies. Plant Foods Hum Nutr. 2024;79(2):359 [Crossref]
5- Shahid I, Shoaib M, Raza R, Jahangir M, Abbasi S, Riasat A, Akbar A, Mehnaz S. In-silico Evaluation of Novel Honokiol Derivatives against Breast Cancer Target Protein LKB1. ACAMC. 2023;23(12):1388 [Crossref]
6- Aboutalebi Vand Beilankouhi E, Vaez-Gharamaleki Y, Zarezadeh R, Hassani P, Amini M, Safaralizadeh R, Valilo M, Wong P. Tamoxifen and the Risk of Breast Cancer in Women With Different Types of Mutation. European Journal of Cancer Care. 2025;2025(1) [Crossref]
7- Hammouda M, Elmaaty A, Nafie M, Abdel-Motaal M, Mohamed N, Tantawy M, Belal A, Alnajjar R, Eldehna W, Al‐Karmalawy A. Design and synthesis of novel benzoazoninone derivatives as potential CBSIs and apoptotic inducers: In Vitro, in Vivo, molecular docking, molecular dynamics, and SAR studies. Bioorganic Chemistry. 2022;127:105995 [Crossref]
8- Sabry Y, Hussein M, Elshal M. Cucurbitacin‐E‐Glucoside Augments Tamoxifen's Anticancer Efficacy by Targeting PPARγ and NF‐kB: In Vivo and In Silico Studies. J Biochem & Molecular Tox. 2025;39(10) [Crossref]
9- Elebeedy D, Ghanem A, El-Sayed M, Fayad E, Abu Ali O, Alyamani A, Sayed Abdelgeliel A. Synergistic Antimicrobial Effect of Lactiplantibacillus plantarum and Lawsonia inermis Against Staphylococcus aureus. IDR. 2022;Volume 15:545 [Crossref]
10- Pallar R, Pingle S, Gaikwad A, Yennam N, Raju N, Kumar P, Adepu V, Tumane R, Veeranjaneyulu C, Matte K. Lectin: A Molecular Tool in Cancer Diagnosis and Therapy with Special Reference to Reproductive Cancers. Mol Biotechnol. 2025;67(2):456 [Crossref]
11- Al-Karmalawy A, Nafie M, Shaldam M, Elmaaty A, Antar S, El-Hamaky A, Saleh M, Elkamhawy A, Tawfik H. Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations. J Med Chem. 2023;66(1):777 [Crossref]
12- Elmaaty A, Darwish K, Chrouda A, Boseila A, Tantawy M, Elhady S, Shaik A, Mustafa M, Al-karmalawy A. In Silico and In Vitro Studies for Benzimidazole Anthelmintics Repurposing as VEGFR-2 Antagonists: Novel Mebendazole-Loaded Mixed Micelles with Enhanced Dissolution and Anticancer Activity. ACS Omega. 2022;7(1):875 [Crossref]
13- Shalaby A, Eid H, El-Shiekh R, Mohamed O, Tripathi A, Al-Karmalawy A, Sleem A, Morsy F, Ibrahim K, Tadros S, Youssef F. Taming Food–Drug Interaction Risk: Potential Inhibitory Effects of Citrus Juices on Cytochrome Liver Enzymes Can Safeguard the Liver from Overdose Paracetamol-Induced Hepatotoxicity. ACS Omega. 2023;8(29):26444 [Crossref]
14- Diab R, Abdel-Sami Z, Abdel-Aal E, Al-Karmalawy A, Abo-Dya N. Design and synthesis of a new series of 3,5-disubstituted-1,2,4-oxadiazoles as potential colchicine binding site inhibitors: antiproliferative activity, molecular docking, and SAR studies. New J Chem. 2021;45(46):21657 [Crossref]
15- Ezz Eldin R, Al-Karmalawy A, Alotaibi M, Saleh M. Quinoxaline derivatives as a promising scaffold for breast cancer treatment. New J Chem. 2022;46(21):9975 [Crossref]
16- El-Demerdash A, Al-Karmalawy A, Abdel-Aziz T, Elhady S, Darwish K, Hassan A. Investigating the structure–activity relationship of marine natural polyketides as promising SARS-CoV-2 main protease inhibitors. RSC Adv. 2021;11(50):31339 [Crossref]
17- El-Naggar A, Hassan A, Elkaeed E, Alesawy M, Al‐Karmalawy A. Design, synthesis, and SAR studies of novel 4-methoxyphenyl pyrazole and pyrimidine derivatives as potential dual tyrosine kinase inhibitors targeting both EGFR and VEGFR-2. Bioorganic Chemistry. 2022;123:105770 [Crossref]

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