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Pharm Sci. 2021;27(2): 262-267. doi: 10.34172/PS.2020.52

Research Article

Anti-Cancer Effects of Probiotic Lactobacillus acidophilus for Colorectal Cancer Cell Line Caco-2 through Apoptosis Induction

Alireza Isazadeh 1,2 ORCID, Saba Hajazimian 1, Behrouz Shadman 3, Sahar Safaei 1, Ahmad Babazadeh Bedoustani 4, Reza Chavoshi 2, Dariush Shanehbandi 1, Mohammadreza Mashayekhi 2, Mohammadreza Nahaei 5 * ORCID, Behzad Baradaran 1,6 * ORCID

Cited by CrossRef: 26

1- Aghaei E, Soltanzadeh H, Kohan L, Heiat M. Apatinib increases anticancer potential of doxorubicin in breast cancer cells. Mol Biol Rep. 2023;50(12):10137 [Crossref]
2- Al-Asfour A, Bhardwaj R, Karched M. Growth Suppression of Oral Squamous Cell Carcinoma Cells by Lactobacillus Acidophilus. International Dental Journal. 2024;74(5):1151 [Crossref]
3- Sankarapandian V, Venmathi Maran B, Rajendran R, Jogalekar M, Gurunagarajan S, Krishnamoorthy R, Gangadaran P, Ahn B. An Update on the Effectiveness of Probiotics in the Prevention and Treatment of Cancer. Life. 2022;12(1):59 [Crossref]
4- Xu Y, Wu X, Li Y, Liu X, Fang L, Jiang Z. Probiotics and the Role of Dietary Substrates in Maintaining the Gut Health: Use of Live Microbes and Their Products for Anticancer Effects against Colorectal Cancer. J Microbiol Biotechnol. 2024;34(10):1933 [Crossref]
5- Samiei Mosleh I, Karami F, Salahshourifar I, Tajabadi Ebrahimi M, Marvibaigi M. Investigating the effects of Lactobacillus acidophilus and Lactobacillus paracasei supernatant on cervical cancer cells. Physiol Pharmacol. 2023;27(4):426 [Crossref]
6- Esmaeili H, Nasrollahzadeh Sabet M, Mosaed R, Chamanara M, Hadi S, Hazrati E, Farhadi A, Heidari M, Behroozi J. Oleanolic acid increases the anticancer potency of doxorubicin in pancreatic cancer cells. J Biochem & Molecular Tox. 2023;37(10) [Crossref]
7- Zhong H, Jiang J, Hussain M, Zhang H, Chen L, Guan R. The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review. Advanced Science. 2025; [Crossref]
8- Victoria Obayomi O, Folakemi Olaniran A, Olugbemiga Owa S. Unveiling the role of functional foods with emphasis on prebiotics and probiotics in human health: A review. Journal of Functional Foods. 2024;119:106337 [Crossref]
9- Marcia J, Aleman R, Montero-Fernández I, Martín-Vertedor D, Manrique-Fernández V, Moncada M, Kayanush A. Attributes of Lactobacillus acidophilus as Effected by Carao (Cassia grandis) Pulp Powder. Fermentation. 2023;9(5):408 [Crossref]
10- Farhoudi Sefidan Jadid M, Jahangirzadehd G, Behroozi J. Anti-proliferation effects of Apatinib in combination with Curcumin in breast cancer cells. 2023;44(1):27 [Crossref]
11- Abedi A, Tafvizi F, Jafari P, Akbari N. The inhibition effects of Lentilactobacillus buchneri-derived membrane vesicles on AGS and HT-29 cancer cells by inducing cell apoptosis. Sci Rep. 2024;14(1) [Crossref]
12- Maleki M, Soltanzade H, Tanomand A, Shahsavari G. The layered double hydroxide (LDH) nanosheets decrease anticancer potential of Satureja khuzestanica in HepG2 hepatocellular carcinoma cells. Gene Reports. 2021;25:101325 [Crossref]
13- Aghaei E, Soltanzadeh H, Kohan L, Heiat M. Anti-proliferative Effects of Hydroxytyrosol Against Breast Cancer Cell Lines Through Induction of Apoptosis. Gene Cell Tissue. 2022;10(1) [Crossref]
14- Sojan J, Licini C, Marcheggiani F, Carnevali O, Tiano L, Mattioli-Belmonte M, Maradonna F. Bacillus subtilis Modulated the Expression of Osteogenic Markers in a Human Osteoblast Cell Line. Cells. 2023;12(3):364 [Crossref]
15- Heiat M, Rezaei E, Gharechahi J, Abbasi M, Behroozi J, Abyazi M, Baradaran B. Knockdown of SIX4 inhibits pancreatic cancer cells via apoptosis induction. Med Oncol. 2023;40(10) [Crossref]
16- Safavi R, Soltanzadeh H, Hojjati Bonab Z. Scrophularia amplexicaulis increases anti‐cancer potential of doxorubicin in gastric cancer cells. Environmental Toxicology. 2023;38(11):2741 [Crossref]
17- Totmaj M, Dadelahi S, Varmazyar S, Abbasi M. Scrophularıa oxysepala inhibit oral cancer cell line OECM-1 through induction of apoptosis. Human Gene. 2022;34:201080 [Crossref]
18- Sun W, Ma S, Meng D, Wang C, Zhang J. Advances in research on the intestinal microbiota in the mechanism and prevention of colorectal cancer (Review). Mol Med Rep. 2025;31(5):1 [Crossref]
19- Shademan B, Masjedi S, Karamad V, Isazadeh A, Sogutlu F, rad M, Nourazarian A. CRISPR Technology in Cancer Diagnosis and Treatment: Opportunities and Challenges. Biochem Genet. 2022;60(5):1446 [Crossref]
20- Rostami L, Soltanzadeh H, Rad F. Anti-proliferative Effects of Cuminum cyminum Extraction by Co-administration of Layered Double Hydroxide (LDH) Nanosheets on SW480 Colorectal Cancer Cell Line through Apoptosis Induction. CCTR. 2022;18(4):310 [Crossref]
21- Vinothkanna A, Shi‐Liang X, Karthick Rajan D, Prathiviraj R, Sekar S, Zhang S, Wang B, Liu Z, Jia A. Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation. Food Frontiers. 2024;5(4):1476 [Crossref]
22- Singh S, Singh M, Gaur S. Probiotics as multifaceted oral vaccines against colon cancer: A review. Front Immunol. 2022;13 [Crossref]
23- Wang G, Pan L, Guo R. Restoration of miR-200 expression suppresses proliferation and mobility of pancreatic cancer cell. Naunyn-Schmiedeberg's Arch Pharmacol. 2025; [Crossref]
24- Singh R, Shadan A, Ma Y. Biotechnological Applications of Probiotics: A Multifarious Weapon to Disease and Metabolic Abnormality. Probiotics & Antimicro Prot. 2022;14(6):1184 [Crossref]
25- Shakhpazyan N, Mikhaleva L, Bedzhanyan A, Gioeva Z, Sadykhov N, Mikhalev A, Atiakshin D, Buchwalow I, Tiemann M, Orekhov A. Cellular and Molecular Mechanisms of the Tumor Stroma in Colorectal Cancer: Insights into Disease Progression and Therapeutic Targets. Biomedicines. 2023;11(9):2361 [Crossref]

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