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Pharm Sci. 2016;22(4): 234-243. doi: 10.15171/PS.2016.37

Research Article

Preparation and Physicochemical Characterization of Biodegradable mPEG-PCL Core-Shell Micelles for Delivery of Artemisinin

Hamid Reza Kheiri Manjili 1, Hojjat Malvandi 3, Mir-Sajjad Mosavi 1, Hossein Danafar 2,3 *

Cited by CrossRef: 24


1- Nosrati H, Salehiabar M, Davaran S, Danafar H, Manjili H. Methotrexate-conjugated L-lysine coated iron oxide magnetic nanoparticles for inhibition of MCF-7 breast cancer cells. Drug Development and Industrial Pharmacy. 2018;44(6):886 [Crossref]
2- Patra S, Singh M, Wasnik K, Pareek D, Gupta P, Mukherjee S, Paik P. Polymeric Nanoparticle Based Diagnosis and Nanomedicine for Treatment and Development of Vaccines for Cerebral Malaria: A Review on Recent Advancement. ACS Appl Bio Mater. 2021;4(10):7342 [Crossref]
3- Chithra P, Bhatia D, Solanki R. Advanced nanomicelles for targeted glioblastoma multiforme therapy. Biomaterials Advances. 2025;170:214221 [Crossref]
4- Gharebaghi F, Dalali N, Ahmadi E, Danafar H. Preparation of wormlike polymeric nanoparticles coated with silica for delivery of methotrexate and evaluation of anticancer activity against MCF7 cells. J Biomater Appl. 2017;31(9):1305 [Crossref]
5- Manjili H, Malvandi H, Mousavi M, Attari E, Danafar H. In vitro and in vivo delivery of artemisinin loaded PCL–PEG–PCL micelles and its pharmacokinetic study. Artificial Cells, Nanomedicine, and Biotechnology. 2018;46(5):926 [Crossref]
6- Danafar H, Jaberizadeh H, Andalib S. In vitro and in vivo delivery of gliclazide loaded mPEG-PCL micelles and its kinetic release and solubility study. Artificial Cells, Nanomedicine, and Biotechnology. 2017;:1 [Crossref]
7- Nabitabar M, Shaterian M, Danafar H, Enhessari M. Multi-wall carbon Nanotube surface-based functional nanoparticles for stimuli-responsive dual pharmaceutical compound delivery. Sci Rep. 2024;14(1) [Crossref]
8- Caldas B, Lazarin-Bidóia D, Nakamura C, Halila S, Borsali R, Muniz E. Drug carrier systems made from self-assembled glyco-nanoparticles of maltoheptaose-b-polyisoprene enhanced the distribution and activity of curcumin against cancer cells. Journal of Molecular Liquids. 2020;309:113022 [Crossref]
9- Hami Z. A Brief Review on Advantages of Nano-based Drug Delivery Systems. Ann Mil Health Sci Res. 2021;19(1) [Crossref]
10- Wen L, Liu H, Hu C, Wei Z, Meng Y, Lu C, Su Y, Lu L, Liang H, Xu Q, Zhan M. Thermoacoustic Imaging-Guided Thermo-Chemotherapy for Hepatocellular Carcinoma Sensitized by a Microwave-Responsive Nitric Oxide Nanogenerator. ACS Appl Mater Interfaces. 2023;15(8):10477 [Crossref]
11- Chen Y, Chen X, Chen Y, Wei H, Lin S, Tian H, Lin T, Zhao J, Gu X, Crispi S. Preparation, characterisation, and controlled release of sex pheromone-loaded MPEG-PCL diblock copolymer micelles for Spodoptera litura (Lepidoptera: Noctuidae). PLoS ONE. 2018;13(9):e0203062 [Crossref]
12- Bhargave H, Nijhawan H, Yadav K. PEGylated Erlotinib HCl Injectable Nanoformulation for Improved Bioavailability. AAPS PharmSciTech. 2023;24(4) [Crossref]
13- Gholami M, Danafer H, Sadeghi M, Daryani A, Hosseini S, Gholami S. Study of anti-Toxoplasma gondii effect of mPEG–PCL copolymeric loaded with pyrimethamine, in vitro. AMB Expr. 2025;15(1) [Crossref]
14- Xu P, Wang X, Li T, Li L, Wu H, Tu J, Zhang R, Zhang L, Guo Z, Chen Q. Bioinspired Microenvironment Responsive Nanoprodrug as an Efficient Hydrophobic Drug Self-Delivery System for Cancer Therapy. ACS Appl Mater Interfaces. 2021;13(29):33926 [Crossref]
15- Li X, Wang Y, Xu F, Zhang F, Xu Y, Tang L, Webster T.

Artemisinin Loaded mPEG-PCL Nanoparticle Based Photosensitive Gelatin Methacrylate Hydrogels for the Treatment of Gentamicin Induced Hearing Loss

. IJN. 2020;Volume 15:4591 [Crossref]
16- Rashidzadeh H, Tabatabaei Rezaei S, Adyani S, Abazari M, Rahamooz Haghighi S, Abdollahi H, Ramazani A. Recent advances in targeting malaria with nanotechnology-based drug carriers. Pharmaceutical Development and Technology. 2021;26(8):807 [Crossref]
17- Kheiri Manjili H, Sharafi A, Attari E, Danafar H. Pharmacokinetics and in vitro and in vivo delivery of sulforaphane by PCL–PEG–PCL copolymeric-based micelles. Artificial Cells, Nanomedicine, and Biotechnology. 2017;45(8):1728 [Crossref]
18- Santos J, Azevedo R, Prudêncio M, Marques F, Le Gal Y, Lorcy D, Fernandes C. Block Copolymer Micelles Encapsulating Au(III) Bis(Dithiolene) Complexes as Promising Nanostructures with Antiplasmodial Activity. Pharmaceutics. 2023;15(3):1030 [Crossref]
19- Casanova M, Vanelle P, Azas N, Broggi J. A how-to guide through the physicochemical and biological methods for the development of polymeric drug delivery systems: Antimalarial vectors as study case. Next Materials. 2025;6:100394 [Crossref]
20- Dadashpour M, Ganjibakhsh M, Mousazadeh H, Nejati K. Increased Pro-Apoptotic and Anti-Proliferative Activities of Simvastatin Encapsulated PCL-PEG Nanoparticles on Human Breast Cancer Adenocarcinoma Cells. J Clust Sci. 2023;34(1):211 [Crossref]
21- Ramazani A, Keramati M, Malvandi H, Danafar H, Kheiri Manjili H. Preparation and in vivo evaluation of anti-plasmodial properties of artemisinin-loaded PCL–PEG–PCL nanoparticles. Pharmaceutical Development and Technology. 2018;23(9):911 [Crossref]
22- Jangid A, Solanki R, Jadav M, Bora S, Patel S, Pooja D, Kulhari H. Phenyl boronic acid -PEG-stearic acid biomaterial-based and sialic acid targeted nanomicelles for colon cancer treatment. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2023;656:130445 [Crossref]
23- Cheng W, Lin S, Chuang K, Chen M, Ho H, Chen L, Hsieh C, Sheu M. Combined Docetaxel/Pictilisib-Loaded mPEGylated Nanocarriers with Dual HER2 Targeting Antibodies for Synergistic Chemotherapy of Breast Cancer. IJN. 2022;Volume 17:5353 [Crossref]
24- Pradhan S, Mishra A, Sahoo S, Pradhan S, Babu P, Singh Y, Chanu N. Artemisinin Based Nanomedicine for Therapeutic Applications: Recent Advances and Challenges. Pharmacological Research - Modern Chinese Medicine. 2022;2:100064 [Crossref]

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