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Pharm Sci. 2017;23(4): 256-263. doi: 10.15171/PS.2017.38

Research Article

Wound Healing Potential of Methanolic Extract of Scrophularia striata in Rats

Ali Ghashghaii 1 * , Mohammad Hashemnia 2, Zahra Nikousefat 1, Mohammad Mahdi Zangeneh 2, Akram Zangeneh 2

Cited by CrossRef: 81


1- Panahi N, Hashemnia M, Rezaei F, Cheraghi H. Effect of Piascledine‐bacterial nanocellulose combination on experimental cutaneous wound healing in rat: Histopathological, biochemical and molecular studies. International Wound Journal. 2024;21(2) [Crossref]
2- Zangeneh M, Joshani Z, Zangeneh A, Miri E. Green synthesis of silver nanoparticles using aqueous extract of Stachys lavandulifolia flower, and their cytotoxicity, antioxidant, antibacterial and cutaneous wound‐healing properties. Applied Organom Chemis. 2019;33(9) [Crossref]
3- Zangeneh M. Green synthesis and chemical characterization of silver nanoparticles from aqueous extract of Falcaria vulgaris leaves and assessment of their cytotoxicity and antioxidant, antibacterial, antifungal and cutaneous wound healing properties. Applied Organom Chemis. 2019;33(9) [Crossref]
4- Erdogan S, Gur T, Terzi N, Dogan B. Evaluation of the cutaneous wound healing potential of tamanu oil in wounds induced in rats. J Wound Care. 2021;30(Sup9a):Vi [Crossref]
5- Xiu J, Zhang Y, Paray B, Gulnaz A, War M. Facile preparation of Fe2O3 nanoparticles mediated by Centaurea alba extract and assessment of the anti-atherosclerotic properties. Arabian Journal of Chemistry. 2022;15(1):103493 [Crossref]
6- Zangeneh M, Zangeneh A, Almasi M, Tahvilian R, Hosseini F, Moradi R. A comparative study of hepatoprotective effect of Inula britannica L aqueous extract and glibenclamide in streptozotocin-induced diabetic mice. Comp Clin Pathol. 2018;27(6):1649 [Crossref]
7- Hu X, Ahmeda A, Zangeneh M. Chemical characterization and evaluation of antimicrobial and cutaneous wound healing potentials of gold nanoparticles usingAllium saralicumR.M. Fritsch. Applied Organom Chemis. 2020;34(4) [Crossref]
8- Naghavi M, Tamri P, Soleimani Asl S. Investigation of Healing Effects of Cinnamic Acid in a Full-Thickness Wound Model in Rabbit. Jundishapur J Nat Pharm Prod. 2021;16(1) [Crossref]
9- Hou H, Mahdavi B, Paydarfard S, Mahdi Zangeneh M, Zangeneh A, Sadeghian N, Taslimi P, Erduran V, Sen F. Retraction Note: Novel green synthesis and antioxidant, cytotoxicity, antimicrobial, antidiabetic, anticholinergics, and wound healing properties of cobalt nanoparticles containing Ziziphora clinopodioides Lam leaves extract. Sci Rep. 2020;10(1) [Crossref]
10- Zangeneh M, Zangeneh A, Amiri H, Amiri N, Tahvilian R, Moradi R, Zhaleh H, Tehrani P. Nephroprotective activity of Alyssum meniocoides Boiss aqueous extract on streptozotocin-induced diabetic nephrotoxicity in male mice. Comp Clin Pathol. 2018;27(5):1147 [Crossref]
11- Zangeneh M, Salmani S, Zangeneh A, Khedri R, Zarei M. Histopathological and biochemical effects of aqueous extract of Tragopogon graminifolius on the liver tissues of Wistar rats fed with high-fat diet. Comp Clin Pathol. 2019;28(5):1197 [Crossref]
12- Fazeli-Nasab B, Shahraki-Mojahed L, Jahantigh M, Dahmardeh N. Scrophularia striata: Therapeutic and Healing Properties with an Emphasis on Oxidative Stress and Gastric Ulcer Treatment. Gene Cell Tissue. 2022;9(4) [Crossref]
13- Ahmeda A, Abbasi N, Ghaneialvar H, Zangeneh M, Zangeneh A. Application of titanium nanoparticles containing natural compounds in cutaneous wound healing. Applied Organom Chemis. 2020;34(4) [Crossref]
14- Goorani S, Zhaleh M, Hajialiani M, Moradi R, Koohi M, Rashidi K, Zangeneh M, Zangeneh A. Hepatoprotective potential of aqueous extract of Allium eriophyllum Boiss in high-fat diet-induced fatty liver diseases. Comp Clin Pathol. 2019;28(4):963 [Crossref]
15- Sahraei M, Zangeneh M, Khanahmadi M, Moradi R, Kazemi N, Zhaleh H, Amini K. The effect of Descurainia sophia oil on methamphetamine-induced cell cytotoxicity and cell death in PC12. Comp Clin Pathol. 2019;28(4):1143 [Crossref]
16- Zarshenas M, Mousavi S, Haghighi T. A critical overview of Scrophularia striata Boiss.: Phytochemical and pharmacological investigations. Pharmacological Research - Modern Chinese Medicine. 2022;5:100182 [Crossref]
17- Zou X, Chen J, Hu J. WITHDRAWN: Green synthesis of cobalt nanoparticles using Calendula officinalis leaves extract: Chemical characterization and anti-lung cancer activity. Inorganic Chemistry Communications. 2022;:109694 [Crossref]
18- Zangeneh A, Pooyanmehr M, Zangeneh M, Moradi R, Rasad R, Kazemi N. Therapeutic effects of Glycyrrhiza glabra aqueous extract ointment on cutaneous wound healing in Sprague Dawley male rats. Comp Clin Pathol. 2019;28(5):1507 [Crossref]
19- Ahmeda A, Zangeneh A, Kalbasi R, Seydi N, Zangeneh M, Mansouri S, Goorani S, Moradi R. Green synthesis of silver nanoparticles from aqueous extract of Ziziphora clinopodioides Lam and evaluation of their bio‐activities under in vitro and in vivo conditions. Applied Organom Chemis. 2020;34(4) [Crossref]
20- Seydi N, Mahdavi B, Paydarfard S, Zangeneh A, Zangeneh M, Najafi F, Jalalvand A, Pirabbasi E. Preparation, characterization, and assessment of cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing properties of titanium nanoparticles using aqueous extract of Ziziphora clinopodioides Lam leaves. Applied Organom Chemis. 2019;33(9) [Crossref]
21- Zangeneh M, Zangeneh A, Tahvilian R, Moradi R, Zhaleh H, Amiri-Paryan A, Bahrami E. Hepatoprotective and hematoprotective effects of Falcaria vulgaris aqueous extract against CCl4-induced hepatic injury in mice. Comp Clin Pathol. 2018;27(5):1359 [Crossref]
22- Zangeneh M, Zangeneh A, Seydi N, Moradi R. Evaluation of cutaneous wound healing activity of Ocimum basilicum aqueous extract ointment in rats. Comp Clin Pathol. 2019;28(5):1447 [Crossref]
23- Zarei H, Tamri P, Asl S, Soleimani M, Moradkhani S. Hydroalcoholic Extract of Scrophularia Striata Attenuates Hypertrophic Scar, Suppresses Collagen Synthesis, and Stimulates MMP2 and 9 Gene Expression in Rabbit Ear Model. J Pharmacopuncture. 2022;25(3):258 [Crossref]
24- Goorani S, Morovvati H, Zangeneh M, Zangeneh A, Seydi N, Moradi R. Experimental study on Wistar rats: the Allium eriophyllum Boiss aqueous extract ointment effectively treat induced cutaneous wound. Comp Clin Pathol. 2019;28(5):1431 [Crossref]
25- Zhaleh M, Zangeneh M, Zangeneh A, Moradi R, Zhaleh H. Antioxidant, cytotoxic, and wound healing effects of Allium saralicum R.M. Fritsch aqueous extract ointment in male rats: a gross, histological, and biochemical experiment. Comp Clin Pathol. 2019;28(5):1421 [Crossref]
26- Mohammadi G, Zangeneh M, Zangeneh A, Haghighi Z. Chemical characterization and anti‐breast cancer effects of silver nanoparticles using Phoenix dactylifera seed ethanolic extract on 7,12‐Dimethylbenz[a] anthracene‐induced mammary gland carcinogenesis in Sprague Dawley male rats. Applied Organom Chemis. 2020;34(1) [Crossref]
27- Hemmati S, Ahmeda A, Salehabadi Y, Zangeneh A, Zangeneh M. Synthesis, characterization, and evaluation of cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing effects of copper nanoparticles using the aqueous extract of Strawberry fruit and l-Ascorbic acid. Polyhedron. 2020;180:114425 [Crossref]
28- Goorani S, Zhaleh M, Koohi M, Seydi N, Rashidi K, Zangeneh M, Zangeneh A. The therapeutic potential of aqueous extract of Falcaria vulgaris in the treatment of fatty liver disease: a histopathological and biochemical approach. Comp Clin Pathol. 2019;28(4):955 [Crossref]
29- An X, Gao Y, Liu X, Yin Q, Meng L, Wei L. Gold nanoparticles green-mediated by Descurainia sophia extract for the treatment of ovalbumin-induced asthma in rats. Inorganic Chemistry Communications. 2024;161:112011 [Crossref]
30- Zhu B, Xie N, Yue L, Wang K, Bani-Fwaz M, Hussein Osman H, El-kott A, Bai X. Formulation and characterization of a novel anti-human endometrial cancer supplement by gold nanoparticles green-synthesized using Spinacia oleracea L. Leaf aqueous extract. Arabian Journal of Chemistry. 2022;15(3):103576 [Crossref]
31- Babaiedarzi A, Ghanbari S, Mehrad seresht M, Nasiri M. Antidiabetic effects of Scrophularia striata ethanolic extract via suppression of Pdx1 and Ins1 expression in pancreatic tissues of diabetic rats. Sci Rep. 2022;12(1) [Crossref]
32- Elyasi B, Zhaleh M, Amini K, Zhaleh H, Khanahmadi M, Moradi R, Kazemi N. Chemical Characterization and Suppressor Potent of Juglans regia Essential Oil on Tramadol-Induced Cell Death. Journal of Essential Oil Bearing Plants. 2020;23(4):849 [Crossref]
33- Ma H, Wang C, Li X, Sui D, Xu S. Efficiency of the green formulated iron nanoparticles as a new tool in lung cancer therapy. Arabian Journal of Chemistry. 2023;16(8):104928 [Crossref]
34- Goorani S, Zangeneh M, Koohi M, Seydi N, Zangeneh A, Souri N, Hosseini M. Assessment of antioxidant and cutaneous wound healing effects of Falcaria vulgaris aqueous extract in Wistar male rats. Comp Clin Pathol. 2019;28(2):435 [Crossref]
35- Amri J, Jamalian M, Salami Z, Akbari A, Alaee M, Soleiman F, Alimoradian A. Hydroalcoholic extract of Scrophularia striata has a significant therapeutic effect on thioacetamide-induced liver cirrhosis in rats. 2024;44(4):371 [Crossref]
36- Wang Y, Chinnathambi A, Nasif O, Alharbi S. Green synthesis and chemical characterization of a novel anti-human pancreatic cancer supplement by silver nanoparticles containing Zingiber officinale leaf aqueous extract. Arabian Journal of Chemistry. 2021;14(4):103081 [Crossref]
37- Zangeneh M, Ghaneialvar H, Akbaribazm M, Ghanimatdan M, Abbasi N, Goorani S, Pirabbasi E, Zangeneh A. Novel synthesis of Falcaria vulgaris leaf extract conjugated copper nanoparticles with potent cytotoxicity, antioxidant, antifungal, antibacterial, and cutaneous wound healing activities under in vitro and in vivo condition. Journal of Photochemistry and Photobiology B: Biology. 2019;197:111556 [Crossref]
38- Alizadeh M, Rezakhani L, Taghdiri Nooshabadi V, Alizadeh A. The effect of Scrophularia striata on cell attachment and biocompatibility of decellularized bovine pericardia. Cell Tissue Bank. 2022;23(2):261 [Crossref]
39- Zangeneh M, Zangeneh A, Bahrami E, Almasi M, Amiri-Paryan A, Tahvilian R, Moradi R. Evaluation of hematoprotective and hepatoprotective properties of aqueous extract of Ceterach officinarum DC against streptozotocin-induced hepatic injury in male mice. Comp Clin Pathol. 2018;27(6):1427 [Crossref]
40- Zangeneh M, Zangeneh A, Tahvilian R, Moradi R, Tehrani P. Preclinical evaluation of hematoprotective and nephroprotective activities of Bellis perennis L aqueous extract on CCl4-induced renal injury in mice. Comp Clin Pathol. 2018;27(6):1557 [Crossref]
41- Moradi R, Hajialiani M, Salmani S, Almasi M, Zangeneh A, Zangeneh M. Effect of aqueous extract of Allium saralicum R.M. Fritsch on fatty liver induced by high-fat diet in Wistar rats. Comp Clin Pathol. 2019;28(5):1205 [Crossref]
42- Bulama I, Kabara H, Zarami A, Atiku M, Wudil A, Ngulde S, Waziri A, Sanda K, Suleiman N, Omeh J. Hepatocurative effect of aqueous extract of Scoparia dulcis (sweet broom) root on carbon tetrachloride-induced hepatotoxicity in albino rats. Comp Clin Pathol. 2020;29(4):807 [Crossref]
43- Ding W, Liang Z, El-Kott A, El-Kenawy A. Investigation of anti-human ovarian cancer effects of decorated Au nanoparticles on Thymbra spicata extract modified Fe3O4 nanoparticles. Arabian Journal of Chemistry. 2021;14(7):103205 [Crossref]
44- Goorani S, Morovvati H, Seydi N, Almasi M, Amiri-Paryan A, Nazari F, Zangeneh M, Zangeneh A. Hepatoprotective and cytotoxicity properties of aqueous extract of Glycyrrhiza glabra in Wistar rats fed with high-fat diet. Comp Clin Pathol. 2019;28(5):1305 [Crossref]
45- Zhao L, Lan T, Jiang G, Yan B. Protective effect of the gold nanoparticles green synthesized by Calendula officinalis L. extract on cerebral ischemia stroke-reperfusion injury in rats: A preclinical trial study. Inorganic Chemistry Communications. 2022;141:109486 [Crossref]
46- Hamelian M, Zangeneh M, Shahmohammadi A, Varmira K, Veisi H. Pistacia atlantica leaf extract mediated synthesis of silver nanoparticles and their antioxidant, cytotoxicity, and antibacterial effects under in vitro condition. Applied Organom Chemis. 2020;34(1) [Crossref]
47- Bai J, Gongsun X, Xue L, Zangeneh M. Introducing a modern chemotherapeutic drug formulated by iron nanoparticles for the treatment of human lung cancer. Journal of Experimental Nanoscience. 2021;16(1):397 [Crossref]
48- Wei N, Hu Z, Xue J, Wen J, Yang C, Gong H. Introducing a Modern Chemotherapeutic Drug Formulated by Etlingera velutina Essential Oil for the Treatment of Human Gastric Cancer. Journal of Essential Oil Bearing Plants. 2022;25(5):967 [Crossref]
49- Gu J, Chen F, Zheng Z, Bi L, Morovvati H, Goorani S. Novel green formulation of copper nanoparticles by Foeniculum vulgare: Chemical characterization and determination of cytotoxicity, anti-human lung cancer and antioxidant effects. Inorganic Chemistry Communications. 2023;150:110442 [Crossref]
50- Zangeneh M, Salmani S, Zangeneh A, Bahrami E, Almasi M. Antiulcer activity of aqueous extract of leaves of Mentha piperita in Wistar rats. Comp Clin Pathol. 2019;28(2):411 [Crossref]
51- Alaribe F, Motaung K. Medicinal Plants in Tissue Engineering and Regenerative Medicine in the African Continent. Tissue Engineering Part A. 2019;25(11-12):827 [Crossref]
52- Zangeneh M, Zangeneh A, Moradi R, Seydi N. Pharmacological, biochemical, and histopathological evaluations of cutaneous wound healing property of Mentha piperita aqueous extract ointment. Comp Clin Pathol. 2019;28(4):1181 [Crossref]
53- Mahdavi B, Saneei S, Qorbani M, Zhaleh M, Zangeneh A, Zangeneh M, Pirabbasi E, Abbasi N, Ghaneialvar H. Ziziphora clinopodioides Lam leaves aqueous extract mediated synthesis of zinc nanoparticles and their antibacterial, antifungal, cytotoxicity, antioxidant, and cutaneous wound healing properties under in vitro and in vivo conditions. Applied Organom Chemis. 2019;33(11) [Crossref]
54- Zangeneh M, Pooyanmehr M, Zangeneh A. Biochemical, histopathological, and pharmacological evaluations of cutaneous wound healing properties of Quercus brantii ethanolic extract ointment in male rats. Comp Clin Pathol. 2019;28(5):1483 [Crossref]
55- Hou H, Mahdavi B, Paydarfard S, Zangeneh M, Zangeneh A, Sadeghian N, Taslimi P, Erduran V, Sen F. RETRACTED ARTICLE: Novel green synthesis and antioxidant, cytotoxicity, antimicrobial, antidiabetic, anticholinergics, and wound healing properties of cobalt nanoparticles containing Ziziphora clinopodioides Lam leaves extract. Sci Rep. 2020;10(1) [Crossref]
56- Zheng J, Karmakar B, El-kott A, Elsaid F, Shati A, Negm S, Alsayegh A, El-Saber Batiha G. Characterization and cytotoxicity and antihuman renal cell carcinoma potentials of starch capped-copper oxide nanoparticles synthesized by ultrasonic irradiation: Introducing a novel chemotherapeutic drug. Journal of Saudi Chemical Society. 2022;26(6):101543 [Crossref]
57- Tamri P. A mini-review on phytochemistry and pharmacological activities of Scrophularia striata. J Herbmed Pharmacol. 2019;8(2):85 [Crossref]
58- Zangeneh M, Zangeneh A, Tahvilian R, Moradi R. Evaluation of the nephroprotective effect of Glycyrrhiza glabra L aqueous extract on CCl4-induced nephrotoxicity in mice. Comp Clin Pathol. 2018;27(5):1119 [Crossref]
59- Zangeneh M, Zangeneh A. Biosynthesis of iron nanoparticles using Allium eriophyllum Boiss extract: Chemical characterization, antioxidant, cytotoxicity, antibacterial, antifungal, and cutaneous wound healing effects. Applied Organom Chemis. 2020;34(1) [Crossref]
60- Konda P, Nagalapuram R, Venkateswarlu J, Mohammad S, Chippada A. Pathophysiology of STZ-induced pancreatic β cell injury and dysfunction: traditional role of Boswellia ovalifoliolata Bal. & Henry on diabetes and dyslipidemia. Comp Clin Pathol. 2020;29(3):609 [Crossref]
61- Dou L, Zhang X, Zangeneh M, Zhang Y. Efficient biogenesis of Cu2O nanoparticles using extract of Camellia sinensis leaf: Evaluation of catalytic, cytotoxicity, antioxidant, and anti-human ovarian cancer properties. Bioorganic Chemistry. 2021;106:104468 [Crossref]
62- Abbasi N, Ghaneialvar H, Moradi R, Zangeneh M, Zangeneh A. Formulation and characterization of a novel cutaneous wound healing ointment by silver nanoparticles containing Citrus lemon leaf: A chemobiological study. Arabian Journal of Chemistry. 2021;14(7):103246 [Crossref]
63- Mahdavi B, Paydarfard S, Zangeneh M, Goorani S, Seydi N, Zangeneh A. Assessment of antioxidant, cytotoxicity, antibacterial, antifungal, and cutaneous wound healing activities of green synthesized manganese nanoparticles using Ziziphora clinopodioides Lam leaves under in vitro and in vivo condition. Applied Organom Chemis. 2020;34(1) [Crossref]
64- Mousavi S, Karami A, Haghighi T, Alizadeh S, Maggi F. Phytotoxic Potential and Phenolic Profile of Extracts from Scrophularia striata. Plants. 2021;10(1):135 [Crossref]
65- Ni J, Negm S, El-kott A, Ghamry H, Karmakar B. Panax ginseng leaf aqueous extract mediated green synthesis of AgNPs under ultrasound condition and investigation of its anti-lung adenocarcinoma effects. 2023;21(1) [Crossref]
66- Minaiyan M, Pasandideh-Fetrat P, Sadeghi-Dinani M, Talebi A. Ameliorative effect of aqueous and hydroalcoholic extracts of Scrophularia striata Boiss. on murine model of experimental colitis. Adv Biomed Res. 2023;12(1):105 [Crossref]
67- Meng L, Li S, Wanyan C. Design and evaluation of a novel nano copper/chitosan–starch bio-composite on antimicrobial property and wound-healing efficacy. Inorganic Chemistry Communications. 2022;140:109433 [Crossref]
68- Zangeneh M, Bovandi S, Gharehyakheh S, Zangeneh A, Irani P. Green synthesis and chemical characterization of silver nanoparticles obtained using Allium saralicum aqueous extract and survey of in vitro antioxidant, cytotoxic, antibacterial and antifungal properties. Applied Organom Chemis. 2019;33(7) [Crossref]
69- Han Y, Gao Y, Cao X, Zangeneh M, Liu S, Li J. Ag NPs on chitosan-alginate coated magnetite for synthesis of indazolo[2,1-b]phthalazines and human lung protective effects against α-Guttiferin. International Journal of Biological Macromolecules. 2020;164:2974 [Crossref]
70- Li B, Wang Y, Bian Y, Gao Z. Antioxidant, cytotoxicity, and anti-prostate carcinoma effects of CuO nanoparticles containing Thymus vulgaris. mat express. 2023;13(11):1862 [Crossref]
71- Goorani S, Koohi M, Zangeneh M, Seydi N, Zangeneh A, Zid-Abdi P, Moradi M, Zhaleh H. Healing and cytotoxicity potentials of ointment containing aqueous extract of Anethum graveolens on cutaneous wounds in male rats. Comp Clin Pathol. 2019;28(5):1471 [Crossref]
72- Zhaleh M, Zangeneh A, Goorani S, Seydi N, Zangeneh M, Tahvilian R, Pirabbasi E. In vitro and in vivo evaluation of cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound healing properties of gold nanoparticles produced via a green chemistry synthesis using Gundelia tournefortii L. as a capping and reducing agent. Applied Organom Chemis. 2019;33(9) [Crossref]
73- Zangeneh A, Zangeneh M, Moradi R. Ethnomedicinal plant‐extract‐assisted green synthesis of iron nanoparticles usingAllium saralicumextract, and their antioxidant, cytotoxicity, antibacterial, antifungal and cutaneous wound‐healing activities. Applied Organom Chemis. 2020;34(1) [Crossref]
74- Arika W, Kibiti C, Njagi J, Ngugi M. In Vitro Antioxidant Properties of Dichloromethanolic Leaf Extract of Gnidia glauca (Fresen) as a Promising Antiobesity Drug. J Evid Based Complementary Altern Med. 2019;24:2515690X1988325 [Crossref]
75- Zangeneh M, Farzaei M, Goodarzi N, Zangeneh A. Protection of CCl4-induced hepatotoxicity by Trachyspermum ammi essential oil in mice. Comp Clin Pathol. 2018;27(5):1367 [Crossref]
76- Zangeneh M, Zangeneh A, Moradi R, Shahmohammadi A. Chemical Characterization and Antibacterial Activity of the Essential Oil of Coriandrum sativum Leaves in the West of Iran (Kermanshah). Journal of Essential Oil Bearing Plants. 2018;21(5):1349 [Crossref]
77- Goorani S, Morovvati H, Seydi N, Zangeneh A, Zangeneh M. Pharmacological, histopathological, and biochemical assessments of cutaneous wound healing potential of Tragopogon graminifolius aqueous extract ointment in rats. Comp Clin Pathol. 2019;28(5):1439 [Crossref]
78- Han S, Ahmeda A, Jalalvand A, Lu W, Zangeneh M, Zangeneh A. Application of silver nanoparticles containing Gundelia tournefortii L. leaf aqueous extract in the treatment of microbial diseases and cutaneous wound healing. Applied Organom Chemis. 2022;36(12) [Crossref]