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Pharm Sci. 2016;22(4): 217-226. doi: 10.15171/PS.2016.35

Research Article

The Postulated Hepatotoxic Metabolite of Methimazole Causes Mitochondrial Dysfunction and Energy Metabolism Disturbances in Liver

Hossein Niknahad 1,2, Akram Jamshidzadeh 1,2, Reza Heidari 1 * , Narges Abdoli 3, Mohammad Mehdi Ommati 4, Faezeh Jafari 2, Mahdi Zarei 2, Behnam Asadi 2

Cited by CrossRef: 10

1- Jamshidzadeh A, Niknahad H, Heidari R, Azadbakht M, Khodaei F, Arabnezhad M, Farshad O. Propylthiouracil-induced mitochondrial dysfunction in liver and its relevance to drug-induced hepatotoxicity. Pharm Sci. 2017;23(2):95 [Crossref]
2- Ommati M, Jamshidzadeh A, Heidari R, Sun Z, Zamiri M, Khodaei F, Mousapour S, Ahmadi F, Javanmard N, Shirazi Yeganeh B. Carnosine and Histidine Supplementation Blunt Lead-Induced Reproductive Toxicity through Antioxidative and Mitochondria-Dependent Mechanisms. Biol Trace Elem Res. 2019;187(1):151 [Crossref]
3- Ommati M, Arabnezhad M, Farshad O, Jamshidzadeh A, Niknahad H, Retana-Marquez S, Jia Z, Nateghahmadi M, Mousavi K, Arazi A, Azmoon M, Azarpira N, Heidari R. The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice. Front Vet Sci. 2021;8 [Crossref]
4- Zadorozhnii P, Kiselev V, Kharchenko A. In silico toxicity evaluation of Salubrinal and its analogues. European Journal of Pharmaceutical Sciences. 2020;155:105538 [Crossref]
5- Ommati M, Sabouri S, Retana-Marquez S, Nategh Ahmadi H, Arjmand A, Alidaee S, Mazloomi S, Akhlagh A, Abdoli N, Niknahad H, Jamshidzadeh A, Ma Y, Azarpira N, Asefi Y, Heidari R. Taurine Improves Sperm Mitochondrial Indices, Blunts Oxidative Stress Parameters, and Enhances Steroidogenesis and Kinematics of Sperm in Lead-Exposed Mice. Reprod Sci. 2023;30(6):1891 [Crossref]
6- Heidari R, Arabnezhad M, Ommati M, Azarpira N, Ghodsimanesh E, Niknahad H. Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity. Pharm Sci. 2019;25(1):1 [Crossref]
7- Heidari R, Mandegani L, Ghanbarinejad V, Siavashpour A, Ommati M, Azarpira N, Najibi A, Niknahad H. Mitochondrial dysfunction as a mechanism involved in the pathogenesis of cirrhosis-associated cholemic nephropathy. Biomedicine & Pharmacotherapy. 2019;109:271 [Crossref]
8- Ommati M, Heidari R, Ghanbarinejad V, Abdoli N, Niknahad H. Taurine Treatment Provides Neuroprotection in a Mouse Model of Manganism. Biol Trace Elem Res. 2019;190(2):384 [Crossref]
9- Ommati M, Ahmadi H, Sabouri S, Retana‐Marquez S, Abdoli N, Rashno S, Niknahad H, Jamshidzadeh A, Mousavi K, Rezaei M, Akhlagh A, Azarpira N, Khodaei F, Heidari R. Glycine protects the male reproductive system against lead toxicity via alleviating oxidative stress, preventing sperm mitochondrial impairment, improving kinematics of sperm, and blunting the downregulation of enzymes involved in the steroidogenesis. Environmental Toxicology. 2022;37(12):2990 [Crossref]
10- Ommati M, Jamshidzadeh A, Niknahad H, Mohammadi H, Sabouri S, Heidari R, Abdoli N. N-acetylcysteine treatment blunts liver failure-associated impairment of locomotor activity. PharmaNutrition. 2017;5(4):141 [Crossref]

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