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  Abstract View: 31

Review

Solubilization Methods for Paclitaxel and Docetaxel: An Overview

Fariba Pourkarim ORCID logo, Elaheh Rahimpour, Sima Alvani, Abolghasem Jouyban* ORCID logo

Abstract

Cancer is still a serious disease with high incidence over the past decades. Many anticancer drugs are discovered and used to treat cancer, among them, taxanes such as paclitaxel and docetaxel have high lipophilicity and low aqueous solubility which is further magnified considering the strong need for administering them by intravenous infusion. Currently, the poor water-solubility of taxanes is improved by prodrug formation, conjugation, inclusion complexation, micellar solubilization and liposome-based formulations. Recent achievement for solubilization of taxanes are reviewed and critically discussed regarding their pharmaceutical and chemical applications.
Keywords: Paclitaxel, Docetaxel, Taxanes, Poor water-solubility, Solubilization methods
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Submitted: 30 Mar 2021
Revision: 30 May 2021
Accepted: 30 May 2021
ePublished: 23 Jun 2021
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