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  Abstract View: 102

Research Article

Effects of sodium selenite and vitamin E on the development of morphine dependency in mice

Bohloul Habibi-Asl, Alireza Parvizpur, Kiarash Fekri, Hadis Jahanpanah, Hadis Rezaei, Mohammad Charkhpour* ORCID logo

Abstract

Background: Antioxidant drugs may be useful in preventing morphine-induced dependency by suppressing oxidative stress. Vitamin E which has many essential roles in the body is a powerful antioxidant. On the other hand, selenium is an essential trace element that plays a strong role in various biochemical pathways. The aim of this study was to investigate the effects of sodium selenite and vitamin E on morphine-induced dependency in mice.
Methods: Ninety male mice, weighing 20 to 30 g, were randomly divided into 10 groups and were treated as follows: a) Saline and b) morphine groups were pretreated (for 2 days) with normal saline (10 ml.kg-1.day-1, ip) then daily doses of normal saline (10 ml.kg-1.day-1, ip) and morphine (50 mg.kg-1.day-1) were added to the injections for the following 4 days, respectively. c, d, e) Sodium selenite, f, g, h) vitamin E, i) vitamin E solvent (almond oil) and j) co-administration groups were pretreated (for 2 days) with sodium selenite (0.25, 0.5, 1 mg.kg-1.day-1, ip), vitamin E (20, 40, 60 IU.kg-1.day-1, ip), vitamin E solvent (10 ml.kg-1.day-1, ip) and combination of the drugs respectively, then morphine doses (50 mg.kg-1.day-1, ip) were added to the injections for the following 4 days. Withdrawal symptoms were evaluated after injecting naloxone (4 mg/kg/day). Biochemical evaluations were also performed.
Results: The results showed that co-administration of sodium selenite and vitamin E (at low doses) significantly reduced morphine dependency (p < 0.05). Conclusion: Therefore, to reduce dependency, this synergistic effect can be a suitable and efficient approach.
Keywords: Morphine, Sodium selenite, Vitamin E, Mice, Withdrawal syndrome
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Submitted: 15 Aug 2020
Revision: 27 Oct 2020
Accepted: 27 Oct 2020
ePublished: 29 Oct 2020
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