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Submitted: 01 Nov 2025
Revision: 24 Dec 2025
Accepted: 03 Jan 2026
ePublished: 31 Mar 2026
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Pharm Sci. Inpress.
doi: 10.34172/PS.026.43440
  Abstract View: 16

Review Article

Solubility of Pharmaceutical Compounds in Binary Solvents: A Tutorial Review on Numerical Methods

Elaheh Rahimpour ORCID logo, Nima Nazemieh, Tahir Suleymanov, William E Acree Jr., Abolghasem Jouyban* ORCID logo
*Corresponding Author: Email: ajouyban@hotmail.com

Abstract

The current state and the most widely used models used for mathematical representation of the solubility data of pharmaceutical compounds in binary solvents were reviewed briefly. Then the utilizing SPSS software for modeling the solubility data with some well-known mathematical models such as the van’t Hoff, the Apelblat, the combined nearly ideal binary solvent/Redlich-Kister, Jouyban-Acree and the Jouyban-Acree-van’t Hoff, the modified Wilson, and the λh is described as a video file. The video is prepared in two parts. The first part is a general explanation of solubility data and the need for modeling these data. The second part is about how to use SPSS software for data modeling with the mentioned models.
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