Pharm Sci. 2024;30(2): 153-186.
doi: 10.34172/PS.2023.27
  Abstract View: 337
  PDF Download: 360

Review Article

Harnessing Nanotechnology for Optimized Herbal Cancer Treatment: A Comprehensive Review of Nanoscale Drug Delivery Systems

Malihe Sadat Razavi 1,2, Fatemeh Ahmadi 1,2, Pedram Ebrahimnejad 1,2* ORCID logo, Abolfazl Akbarzadeh 3.,4, Masoud Farokhrou 5, Ali Nokhodchi 6,7,8* ORCID logo

1 Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences, Sari, Iran.
2 Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.
3 Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Universal Scientific Education and Research Network (USERN), Tabriz, Iran.
5 Dental Professionals of Coral Springs, Coral Spring, Florida 33065, USA.
6 Lupin Inhalation Research Center, Lupin Pharmaceuticals, 4006 NW 124th Ave., Coral Springs, FL 33065, USA.
7 Pharmaceutics Research Laboratory, School of Life Sciences, University of Sussex, Brighton BN1 9QJ, UK.
8 Daru Vira Iranian Pharmaceutical Group, Isfahan, Iran.
*Corresponding Authors: Email: pebrahimnejad@mazums.ac.ir; Email: a.nokhodchi@sussex.ac.uk


Cancer is widely recognized as the second leading cause of death on a global scale. In recent years, nanotechnology has emerged as a promising strategy in the field of cancer therapy. Nanoscale drug delivery systems, a category of innovative technologies, harness the potential of various nanoparticles and nanomaterials to efficiently transport chemotherapeutic drugs, revolutionizing cancer treatment. The use of natural products has shown substantial promise in both the prevention and therapy of cancer. Herbal medicines, in particular, have gained widespread use due to their inherent therapeutic advantages and notably fewer adverse effects compared to modern drugs. However, their hydrophobic nature has presented a challenge, limiting their bioavailability and therapeutic efficacy. To overcome these limitations, researchers have developed nanocarriers tailored for the delivery of therapeutic agents to specific target cells. The combination of nanocarriers with herbal remedies results in improved bioavailability, enhanced pharmacological activity, and increased stability, all while minimizing systemic toxicity in cancer treatment. This review provides a comprehensive discussion of novel nanocarriers that find application in cancer treatment, with a specific focus on herbal medicine. The amalgamation of these innovative approaches offers promising prospects for the future of cancer therapy.
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Submitted: 28 Aug 2023
Revision: 24 Nov 2023
Accepted: 25 Nov 2023
ePublished: 19 Jan 2024
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