Pharm Sci. 2022;28(1): 86-93.
doi: 10.34172/PS.2021.28

Scopus ID: 85117454075
  Abstract View: 558
  PDF Download: 467

Research Article

Evaluation of the Potential Role of Silver Nanoparticles Loaded with Berberine in Improving Anti-Tumor Efficiency

Mohamed Othman 1,2* ORCID logo, Sofian Obeidat 1, Amal Al-Bagawi 3, Mohamed Fareid 1,4, Ola El-Borady 5, Rami Kassab 6, Ahmed Abdel Moneim 6 ORCID logo

1 Basic Sciences Department, Deanship of Preparatory Year University of Ha’il, Hail, Saudi Arabia.
2 Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza, Egypt.
3 Chemistry Department, Faculty of Science, University of Ha’il, Hail, Saudi Arabia.
4 Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt.
5 Institute of Nanoscience and Nontechnology, Kafrelsheikh University, Egypt.
6 Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt.
*Corresponding Author: Email: biostar55@yahoo.com


Background: Cancer is a progressive disease, its incidence and death rates are rapidly increasing globally. Numerous adverse effects are associated with the available interventions. Hence, the current study was undertaken to explore the anticancer effect of silver nanoparticles conjugated with berberine (AgNPs-BER) against Ehrlich solid carcinoma (ESC) in mice.

Methods: Male Swiss albino mice were allocated randomly into ESC, ESC+cisplatin (CP; 5 mg/kg), ESC+AgNPs-BER (20 mg/kg), and ESC+cisplatin and AgNPs-BER groups.

Results: AgNPs-BER administration increased significantly the survival rate and decreased body weight and tumor size as compared to ESC group. Additionally, AgNPs-BER enhanced the development of oxidative stress in the tumor tissue as indicated by the increased lipid peroxidation (LPO) and nitric oxide (NO) accompanied by a decrease in the examined antioxidant proteins (glutathione (GSH) and its derived enzymes along with superoxide dismutase and catalase). AgNPs-BER was found also to trigger apoptotic cascade in the tumor cells through upregulating the mRNA expression of the pro-apoptotic proteins (Bax and caspase-3) and downregulating the mRNA expression of the anti-apoptotic protein (Bcl-2). Moreover, AgNPs-BER improved partially the histopathological alterations in the developed tumor tissue as compared to ESC group.

Conclusion: Collectively, AgNPs-BER could be applied as an antitumor agent due to its pro-oxidant, pro-apoptotic, and antiangiogenic effects.

First Name
Last Name
Email Address
Security code

Abstract View: 559

Your browser does not support the canvas element.

PDF Download: 467

Your browser does not support the canvas element.

Submitted: 15 Mar 2021
Revision: 16 May 2021
Accepted: 16 May 2021
ePublished: 19 May 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)