Pharm Sci. 2022;28(1): 5-14.
doi: 10.34172/PS.2021.25

Scopus ID: 85127122361
  Abstract View: 416
  PDF Download: 460


Mechanistic Insight on Ras Inhibition Strategies in Cancer Therapy

Jeiran Pashapour-Anousheh 1,2 ORCID logo, Abolfazl Barzegar 3, Mohammad Saeid Hejazi 1,2, Nikoo Hasheminejad 1,2, Hamid Reza Heidari 1,2, Elnaz Mehdizadeh Aghdam 1,2* ORCID logo

1 Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
*Corresponding Author: Email: aghdamelnaz@gmail.com


Ras proteins are considered as one of the most critical cancer initiators. Mutations of this protein family lead to the continuous activation of the proliferation pathways. Therefore, many efforts have been taken to design the anti-mutant Ras drug candidates. Regardless of the development of promising inhibitors of Ras G12C mutant in a specific cancer type, there is no approved inhibitor of Ras mutants in the clinic. One of the significant limitations is to inhibit particular mutants and not to affect the wild-type Ras variants. Here we present a review on the mechanism of action of the Ras proteins to get a better insight into the strategies utilized to inhibit Ras-mutated cancers. The direct Ras inhibition strategies are then highlighted to obtain a better perspective of possible promising approaches to target Ras proteins in cancer therapy.
First Name
Last Name
Email Address
Security code

Abstract View: 410

Your browser does not support the canvas element.

PDF Download: 460

Your browser does not support the canvas element.

Submitted: 12 Dec 2020
Revision: 08 May 2021
Accepted: 08 May 2021
ePublished: 09 May 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)