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Pharm Sci. 2020;26(4): 344-362.
doi: 10.34172/PS.2020.54
  Abstract View: 158
  PDF Download: 215

Review

Vaccinium vitis-idaea L.: Chemical Contents, Pharmacological Activities

Arnold Alexeevich Shamilov 1* ORCID logo, Valentina Nikolaevna Bubenchikova 2 ORCID logo, Maxim Valentinovich Chernikov 3, Dmitryi Igorevich Pozdnyakov 4 ORCID logo, Ekaterina Robertovna Garsiya 1 ORCID logo

1 Department of Pharmacognosy, Botany and Technology of Phytopreparations, Pyatigorsk Medical-Pharmaceutical Institute (PMPI), Branch of Volgograd State Medical University, Ministry of Health of Russia, 11, Kalinina Prospect, Pyatigorsk, Russian Federation, 357532.
2 Department of Pharmacognosy and Botany, Kursk State Medical University (KSMU), Ministry of Health of Russia, 3, K. Marx Street, Kursk, Russian Federation, 305041.
3 Department of Biology and Physiology, Pyatigorsk Medical-Pharmaceutical Institute (PMPI), Branch of Volgograd State Medical University, Ministry of Health of Russia, 11, Kalinina prospect, Pyatigorsk, Russian Federation, 357532.
4 Department of Pharmacology with course of clinical Pharmacology, Pyatigorsk Medical-Pharmaceutical Institute (PMPI), Branch of Volgograd State Medical University, Ministry of Health of Russia, 11, Kalinina prospect, Pyatigorsk, Russian Federation, 357532.

Abstract

One of the most known species of the genus Vaccinium (Ericaceae) is Vaccinium vitis-idaea L. or
lingonberry. Leaves are included in the State Pharmacopoeia of the Russian Federation (XIV-th
edition) and the State Pharmacopoeia of the Republic of Belarus (II-nd edition). The aim of this
review is an analysis of data about a chemical content and types of pharmacological activities
of Vaccinium vitis-idaea L. to discuss the tendency of future investigations on this plant. The
main parts of works describe researches of chemical contents of fruits as medicinal and edible
plant material. The majority of researches describe results of in vitro experiments. A significant
interest is the study of the neuroprotective activity of the Vaccinium vitis-idaea extracts as well
as their anti-cytokine and antiapoptotic properties and metabolic effects. The main biologically
active compounds are phenologlycosides, tannins, proanthocyanes, saponins etc. These results
will be of great significance for the development of new drugs from this plant and use along with
the fruits of other parts of the plant.
Keywords: Phytochemistry, Phytotherapy, Vaccinium, Vaccinium vitis-idaea L.
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Submitted: 15 Feb 2020
Accepted: 09 Jul 2020
ePublished: 25 Dec 2020
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