Pharm Sci. 2021;27(1): 14-31.
doi: 10.34172/PS.2020.25
  Abstract View: 278
  PDF Download: 130


Boswellic Acids as Promising Leads in Drug Development against Alzheimer’s Disease

Hossein Haghaei 1 ORCID logo, Somaieh Soltani 2 ORCID logo, Seyedrafie Aref Hosseini 1* ORCID logo, Mohammad Reza Rashidi 2,3* ORCID logo, Saeed Karima 4 ORCID logo

1 Nutrition and food Sciences Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Drug Applied Research Center and Pharmacy Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Research Center for Pharmaceutical Nanotechnology and Pharmacy Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Clinical Biochemistry, School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.


Biological activity of Boswellia extract (BE) has been attributed to its main active ingredients; i.e. Boswellic acids (BAs). BE/BAs possess a promising therapeutic potential in neurodegenerative disorders; including Alzheimer's disease (AD). The multifactorial nature of AD pathophysiology necessitates the development of the disease-modifying agents (DMA). Recent multi-targeting approaches for the DMAs development have brought more attention to the plant-derived compounds regarding their better human compatibility because of their biologic origin. This review addresses the current knowledge on the anti-AD activity of BE/BAs based on the available in silico, in vitro, in vivo studies and clinical trials. The contribution of BE/BAs in inflammatory pathways, Tau and β-amyloid proteins, microtubule functions, oxidative stress, cholinesterase and diabetes/insulin pathways involved in AD have been discussed. BAs efficacy in different AD-related pathways has been confirmed in vitro and in vivo. They can be considered as valuable scaffold/lead compounds for multi-targeted DMAs in anti-AD drug discovery and development.
Keywords: Alzheimer’s disease, Boswellic acids, Disease-modifying therapeutics, Multi-target drug, Plant derived scaffolds
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Abstract View: 279

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Submitted: 09 Jan 2020
Revision: 11 Mar 2020
Accepted: 11 Mar 2020
ePublished: 18 Mar 2020
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