Pharm Sci. 2019;25(3): 190-197.
doi: 10.15171/PS.2019.36

Scopus ID: 85072811598
  Abstract View: 621
  PDF Download: 397

Research Article

Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Abdelkader Oumeddour 1,2* ORCID logo, Djahida Zaroure 2, Raziqua Haroune 2, Rima Zaimeche 2, Karima Riane 3, Mohamed Sifour 3, Abdelkrim Tahraoui 4

1 Departement des Sciences de la Nature et de la Vie, Université 8 Mai 1945 Guelma, BP 401, Guelma 24000, Algeria.
2 Laboratory of Molecular and Cell Biology, Faculty of Sciences, University Mohamed Seddik Benyahia of Jijel, Algeria.
3 Laboratory of Molecular Toxicology, Faculty of Sciences, University Mohamed Seddik Benyahia of Jijel, Algeria.
4 Laboratoire de Neuro-endocrinologie Appliquée, Département de Biologie, Université Badji Mokhtar, Annaba, Algeria.


Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.
Keywords: Carbon tetrachloride, Propolis, Lactobacillus acidophilus, Oxidative stress, Hepatotoxicity
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Submitted: 10 Feb 2019
Revision: 04 Apr 2019
Accepted: 26 Apr 2019
ePublished: 30 Sep 2019
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