Abstract
Background: Inhibition of
angiotensin converting enzyme (i.e inhibition of cleaving angiotensin I to the
potent vasoconstrictor angiotensin II) leads to the treatment and reduce the
risk of cardiovascular diseases. Peptides (synthetic - natural) with ACE
inhibitory activity were studied continuously during the last decades and
resulting data were applied by medicinal chemists to design and develop new
drugs. Their structure and activity/property relationships were studied during
these years and different QSAR models were developed which assisted researchers
and manufactures to reduce the cost of experiments. Developed models were
reviewed in the present paper according to the applied dataset, descriptors,
feature selection methods, model development and validation methods. The
selected descriptors for different datasets and models were compared and
discussed according to the experimental findings.