Shadi Yaqoubi
1, Mohammad Barzegar Jalali
2, Khosro Adibkia
2, Hamed Hamishehkar
3*1 Biotechnology Research Center and Students’ Research Co mmittee, Tabriz University of Medical Sciences, Tabriz, Iran
2 Research Center for Pharmaceutical Nanotechnology and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract
Background: The objective of the present
study was to investigate the combinative effect of ball milling and solvent
displacement method on size reduction of Celecoxib particles. Celecoxib is a
poorly water soluble cyclooxygenase 2 inhibitor which has a wide range of therapeutic
applicability.
Methods: Microparticles were developed
via solvent displacement method followed by planetary ball milling. In order to
obtain an optimized size and size distribution of Celecoxib microparticles
various factors were evaluated; the role of solvent type, type and
concentration of stabilizer, milling effect, and the effect of milling duration
were the most important factors studied during the present investigation.
Results: All the obtained formulations
were in micron range that the smallest particles had the size of 1.76 μm and
the formulation containing the largest particles was of 8.30 μm by volume mean
diameter. Both solvent displacement and milling methods are common and
potential approaches in order to formulate micron scaled particles.
Conclusion: The combination of these two
methods generates a synergistic effect which leads to smaller particle size and
a narrow size distribution. Celecoxib microparticles have the potential to use
as promising delivery systems to treat various disease and malignancies.