Dario A Tinjaca
1, Maria M Muñoz
1, Fleming Martinez
1* 
, Abolghasem Jouyban
2,3, William E Acree Jr
41 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia -Sede Bogotá, Cra. 30 No. 45-03, Bogotá, D.C., Colombia.
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.
Abstract
Background: Sucrose is the most widely
used sweetener in foods and pharmaceuticals. Apparent specific volumes of this
excipient in aqueous cosolvent mixtures are not available. Thus, the main
objective of this research was to determine this property by measuring the
density of several solutions of sucrose in {cosolvent + water} mixtures at
298.2 K.
Methods: Sucrose dissolutions were
prepared gravimetrically and a thermostatically controlled digital oscillatory
method was used to measure the dissolutions density.
Results: From density values of
sucrose dissolutions and cosolvent mixtures the apparent specific volumes of
sucrose were calculated and analyzed based on the sucrose and cosolvent
proportions in the mixtures.
Conclusion: Useful density values of
sucrose solutions at different concentrations in several aqueous cosolvent
mixtures are reported at 298.2 K. Finally, a mean apparent specific volume
value of 0.632 cm3.g–1 for sucrose in different
aqueous-cosolvent mixtures could be adequate for practical purposes in
pharmaceutical industries.