Pharm Sci. 2018;24(4):324-331.
doi: 10.15171/PS.2018.46

Scopus id: 85060029866
  Abstract View: 107
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Research Article

Apparent Specific Volumes of Sucrose in Different Aqueous Cosolvent Mixtures at 298.2 K

Dario A Tinjaca 1, Maria M Muñoz 1, Fleming Martinez 1 * ORCiD, Abolghasem Jouyban 2,3, William E Acree Jr 4

1 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia -Sede Bogotá, Cra. 30 No. 45-03, Bogotá, D.C., Colombia.
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.

Abstract

Background: Sucrose is the most widely used sweetener in foods and pharmaceuticals. Apparent specific volumes of this excipient in aqueous cosolvent mixtures are not available. Thus, the main objective of this research was to determine this property by measuring the density of several solutions of sucrose in {cosolvent + water} mixtures at 298.2 K. Methods: Sucrose dissolutions were prepared gravimetrically and a thermostatically controlled digital oscillatory method was used to measure the dissolutions density. Results: From density values of sucrose dissolutions and cosolvent mixtures the apparent specific volumes of sucrose were calculated and analyzed based on the sucrose and cosolvent proportions in the mixtures. Conclusion: Useful density values of sucrose solutions at different concentrations in several aqueous cosolvent mixtures are reported at 298.2 K. Finally, a mean apparent specific volume value of 0.632 cm3.g–1 for sucrose in different aqueous-cosolvent mixtures could be adequate for practical purposes in pharmaceutical industries.
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Submitted: 27 Jul 2018
Revised: 02 Sep 2018
Accepted: 15 Sep 2018
First published online: 30 Dec 2018
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