Pharm Sci. 2018;24(2): 163-167.
doi: 10.15171/PS.2018.24

Scopus ID: 85049301646
  Abstract View: 886
  PDF Download: 1374

Short Communication

Solubility and Apparent Specific Volume of Sucrose in Some Aqueous Polyethylene Glycol Mixtures at 298.2 K

Dario A Tinjaca 1, Maria M Muñoz 1, Elaheh Rahimpour 2, Abolghasem Jouyban 2,3, Fleming Martinez 1*, William E Acree Jr 4

1 Grupo de Investigaciones Farmacéutico-Fisicoquímicas, Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia -Sede Bogotá, Cra. 30 No. 45-03, Bogotá, D.C., Colombia.
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Chemistry, University of North Texas, Denton, TX 76203-5070, USA.


Background: Sucrose is the most widely used sweetener in food and pharmaceuticals. Quantitative solubility values of this excipient in aqueous polyethylene glycol (PEG) mixtures is not abundant. Thus, the main objective of this research was to determine and correlate the equilibrium solubility of sucrose in {PEG 200 (or 400) + water} mixtures at 298.2 K. Methods: Shaken flask method was used to determine isothermal solubility. Concentration measurements were performed by means of density determinations. Jouyban-Acree model was used to correlate both solubility sets. Results: Solubility of sucrose decreases non-linearly with the addition of either PEG200 or PEG400 to water. Jouyban-Acree model correlates solubility values with mixtures composition for both cosolvent systems. Moreover, apparent specific volume of sucrose were also calculated from density and compositions. Conclusion: Useful solubility values of sucrose at equilibrium in aqueous mixtures of PEG200 and PEG400, as well as their volumetric contributions to saturated solutions are reported. 
Keywords: Sucrose, PEGs, Solubility, Cosolvency, Apparent specific volume, Jouyban-Acree model
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Submitted: 21 Dec 2017
Revision: 28 Jan 2018
Accepted: 20 Mar 2018
ePublished: 20 Jun 2018
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