Rouhollah Gazor
1, Ardalan Pasdaran Lashgari
2,3,4*, Shabnam Almasi
1, Saeed Ghasemi
51 Department of Anatomy, Faculty of M edicine, Guilan University of Medical Sciences, Rasht, Iran
2 Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Pharmacognosy, School of Pharmacy, Guilan University of Medical Sciences, Rasht, Iran
4 Research and D evelopment C enter of Plants and M edicinal C hemistry, Guilan University of Medical Sciences, Rasht, Iran
5 Department of Medicinal C hemistry, School of Pharmacy, Guilan University of Medical Scienc es, Rasht, Iran
Abstract
Background: C.trinodisis
brown algae of Oman Sea coast is used traditionally as a diuretic in Chabahar,
Sistan and Baluchestan province of Iran. But no researches have been conducted
on the distractive effects of this alga on the renal tissues until now. Methods:
Forty-two adult male mice were divided into 6 groups. Control group received
normal saline (E0), group (E1) treated with 5mg/kg methanolic extract (ME) and
group (E2) to (E5) received 10, 15, 25 and 50 mg/kg of ME of alga respectively.
All animals in 6 groups were treated for 2 weeks (once every other day).
Finally, histopathological evaluations were made especially by morphology and
photometric method.
Results:
ME of C.trinodis induced histological damage in kidney. Administration
of ME in all experimental groups induced severe glomerular congestion, hyaline
cast and severe interstitial inflammatory centers in treated groups. All
distractive parameter in test groups increased with increasing dose of extract
(p<0.05).
Conclusion:
Results showed that ME of the C.trinodis has a nephrotoxic effect on the
renal tissues.