Foroogh Namjoyan
1, Alireza Jahangiri
2, Mohammad Ebrahim Azemi
1, Hamideh Mousavi
3*1 Pharmacognosy Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,
2 Medicinal Chemistry Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, I
3 Medicinal Plant Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,
Abstract
Background: Tyrosinase is a key enzyme in melanin synthesis from
tyrosine. To prevent or treat pigmentation disorders, tyrosinase inhibitors
have been used increasingly for medicinal and cosmetic products.
The aim of this
study is to evaluate inhibitory effects of Urginea maritima (L.) Baker,
Zhumeria majdae Rech.f. & Wendelbo and Physalis divaricata
D.Don on mushroom tyrosinase.
Methods:
The inhibitory activities of the hydroalcoholic extracts of plants against
oxidation of L-DOPA (as a substrate) by mushroom tyrosinase were investigated.
The amount of formed DOPAchrome was determined at 475 nm as optical density.
Results:
The extracts showed anti-tyrosinase activity weaker than positive control
(Kojic acid). The inhibitory activity of tested plants: U.maritima, Z.majdae
and P.divaricata against mushroom tyrosinase were 38.61, 29.70 and 25.74
% at 1.67 mg/mL, respectively.
Conclusion:
The most tyrosinase inhibitory activity
was seen for U.maritima. However more investigations on human
tyrosinase, toxicological and clinical studies are needed to confirm its activity.