Pharm Sci. 2019;25(2): 85-92.
doi: 10.15171/PS.2019.14

Scopus ID: 85069179927
  Abstract View: 688
  PDF Download: 424


Non-Invasive and Less Degradative Ways of Insulin Administration

Saeideh Allahyari 1,2 ORCID logo, Yousef Javadzadeh 3* ORCID logo

1 Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.


Protein and peptide delivery systems attract great attention nowadays. They play crucial role in several diseases, but their way of administration has some disadvantages that makes patients dissatisfied. In this study, we choose insulin as a peptide that is used for type I and type II diabetic patients, but injection way of its usage is not suitable in diabetes as a chronic remedy. Although oral way is a needle-free one, but its bioavailability through that would be decreased because of degradation in gastro-intestine and consequently, further dosage should be used to get the desired hypoglycemic effect. Administration of insulin through non-parenteral and less enzymatic pathways, such as intranasal, pulmonary, transdermal, colon and vaginal routes, is new that attracts researchers’ attention considerably. Although the bioavailability of insulin may be lower than the current injection way, but it may be improved by some strategies like the use of permeation enhancers. There are also some limitations in each way, but propagation of them would result in improvement of patients’ quality of life and may cause some economic profits. The objective of this review was to introduce the convenient ways for long term insulin administration with few enzymatic barriers.
Keywords: insulin, Delivery ways, Non-invasive, Less enzymatic
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Submitted: 18 Dec 2018
Revision: 15 Feb 2019
Accepted: 15 Feb 2019
ePublished: 30 Jun 2019
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