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Pharm Sci. 2019;25(2):171-175.
doi: 10.15171/PS.2019.25
  Abstract View: 92
  PDF Download: 66

Short Communication

Dicaffeoylquinic Acids from the Aerial Parts of Artemisia ciniformis Krasch. & Popov ex Poljakov

Sajjad Nasseri 1,2, Seyed Ahmad Emami 3, Mahdi Mojarrab 2 * ORCiD

1 Students Research Committee, Kermanshah University of Medical Science, Kermanshah, Iran.
2 Pharrmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
3 Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


Background: Artemisia ciniformis (A. ciniformis) belongs to the genus Artemisia and grows at northeast of Iran. The current phytochemical study was carried out on the most potent extract in cell-free antioxidant assays. Methods: Hydroethanolic extract of the aerial parts was fractionated using vacuum-liquid chromatography (VLC). The selected fraction from the previous cell-free antioxidant study was purified by semi-preparative HPLC. The structures of isolated compounds were identified using one- and two-dimensional NMR and ESIMS techniques. Results: Three identified compounds in this study were the known isomers of dicaffeoylquinic acid (DCQ), including 3,5- DCQ (isochlorogenic acid A), 3,4-DCQ (isochlorogenic acid B) and 4,5-DCQ (isochlorogenic acid C). Conclusion: The outstanding free radical scavenging potential in the hydroethanolic extract of A. ciniformis might be partly related to the presence of isochlorogenic acid derivatives.
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Submitted: 14 Nov 2018
Revised: 26 Dec 2018
Accepted: 26 Dec 2018
First published online: 30 Jun 2019
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