Abstract
Background: Hospital-acquired infections are among the most
significant reasons of human mortality world-wide which can be controlled by
efficient application of suitable disinfectant for hospital setting. The main
goal of the present study was to determine the efficacy of eight routinely used
hospital disinfectants against clinical isolates.
Methods: In our
descriptive study, in the first step the antibiogram assay of 99 clinical
isolates enterococci and Pseudomonas aeruginosa were determined. Then,
minimum inhibitory concentration and minimum bactericidal concentration of
isolates against Povidone Iodine 10%, Ethanol 70%, Savlon 3.2%,
Deconex51Gastro, Procept Floor, Septo med, Surfanious and Gigasept AF were
evaluated. Furthermore, the efficacy of disinfectants was reevaluated in
presence of 5% (w/v) Bovine Serum Albumin.
Results: The results showed that Septo med and Surfanious are
the most and less potent disinfectants against clinical isolates, respectively.
It is also resulted that Povidone Iodine is the most effective choice among the
conventional disinfectants in this study. Clearly, addition of 5% organic
substances reduced the efficacy of selected disinfectants significantly.
Conclusion: Novel
quaternary ammonium compounds are the most applicable choice for disinfection
of hospital surfaces and instruments in this study.