Abstract
Nicotine
replacement therapy (NRT) with gradual decreasing of nicotine is one of the
smoking cessation methods. Nicotine dosage forms on the market are including
gum and skin patches. Muccoadhesive formulations are the novel drug delivery
systems that are available in the form of tablets and films, and can be used
for NRT. Muccoadhesive nicotine tablets (MNT) when placed in the upper gum,
will release its nicotine content in a controlled manner. This will meet the
need of the individual to the nicotine, such that the person can decrease
his/her dependency on smoking. Methods: In the current study, the tablets were prepared using
different conventional bioadhesive polymers such as HPMC50cps, NaCMC, and
carbapol934 in singular or mixture form; magnesium hydroxide as the pH
increasing agent; magnesium stearate as the lubricant; and lactose as the
excipiente, of different products of nicotine hydrogen tartrate, which is more
stable than the nicotine. Their pharmaceutics characteristics such as the
degree of adhesion and the rate of drug release were evaluated. Results: Increasing of
HPMC50cps in the
formulations decrease speed release of nicotine. The carbapol in formulations
beget slow releasing of nicotine. With increasing the percent of lactose, the
rate of release in formulations was increased. Formulations which have HPMC 50cps has best adhesiveness. Formulations
contains carbapol had not suitable
adhesiveness. Formulations contains NaCMC were very fast release and had not suitable adhesiveness. Conclusion: The
formulation contains mixture of HPMC50cps and Cp934 with suitable adhesiveness and minimum
fluctuation in release, was the best formulation.