Abstract
It is well known that progesterone (i.p.) have a
potent anticonvulsant effect in human and animal. This study was designed to
evaluate the involvement of opioid receptors in this effect of progesterone in
ovariectomized mice. Methods: All animal received intraperitoneal
injection of drugs (progesterone and naloxone) two week s after surgery, for
ovariectomy. Convulsion induced by subcutaneous injection of drugs. Onset,
Number, death time and duration of convulsion were recorded for evaluation of
the convulsion. Results: Progesterone (25, 50 mg/kg i.p.)
decreased the convulsive symptoms. Anticonvulsant effect of high dose of
progesterone was abolished by naloxone (5 mg/kg i.p.). Administration of the
same doses of the naloxone, did not alone affect strychnine- induced convulsion.
Conclusion: These results suggest that central opioids receptors
may be play an important role in the anticonvulsant effect of progesterone