Atefe Mohammadzadeh Vardin
1, Monireh Khordadmehr
2, Reza Heidari
3, Hedaiat-o-llah Nouri
4, Maryam Bannazadeh Amirkhiz
5, Mehran Mesgari Abbasi
5*1 Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.
3 Faculty of Science, Urmia University, Urmia, Iran.
4 Department of Urology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
5 Student Research Committee, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Abstract
Background: Cisplatin
(Cis) is a chemotherapeutic agent and nephrotoxicity is a serious adverse
effect of the drug. This study investigated the protective effects of Cornus
mas fruit hydro-methanolic extract (CME) on cisplatin-induced
nephrotoxicity in a rat model.
Methods: Forty Wistar rats were divided into the control group, CME group, CME 300 + Cis group, CME 700 + Cis group, and Cis group. After the intervention samples were taken for biochemical and
histopathological analysis.
Results: The CME analysis showed considerable total antioxidant and total phenol
contents. The blood serum urea and creatinine increased (p < 0.01) in the
Cis group rats. In the Cis + CME groups, the parameters were not significantly
different from that of the control group. There were no significant differences
in the renal activities of SOD, GPx, CAT, and TAC between the Cis-treated and
control groups (p > 0.05). The renal MDA levels of the Cis and CME 300 + Cis
groups decreased significantly in comparison to the control and the CME groups
(p < 0.01 and p < 0.05, respectively). In the histopathological
examination, mild to severe degeneration was observed in the Cis group. Despite
the presence of mild degeneration, they were less severe in the Cis + CME
groups, and maintained a better morphology when compared to the Cis group (p
< 0.01).
Conclusion: The results showed renoprotective effects of CME
against Cis-induced nephrotoxicity in rats.