Hamza Belkhodja
1*, Boumediene Meddah
1,2, Aicha Meddah TirTouil
1, Khaled Slimani
3, Abdenacer Tou
41 Laboratory of Bioconversion, Microbiology Engineering and Health Safety, Department of Biology, Faculty SNV, University of Mascara, Algeria
2 Laboratory of Glucides, FRE-CNRS 3517, Faculty of Pharmacy, University of Picardie, Amiens, France
3 Institute of Veterinary Science, Service of Carnivorous Pathologies, University of Ibn Khaldoun, Tiaret, Algeria
4 Service of Pathology, University Hospital of Sidi Bel Abbes, Sidi Bel Abbes, Algeria
Abstract
Background: The
plants represent
an important source of various chemical structures known for their
therapeutic activities in folk
medicine. Our study aimed to exploit natural bioactive components from
well-known medicinal plants "Rosmarinus officinalis and Populus
alba".
Methods: The study of acute toxicity of
essential oils of Rosemary and White poplar was carried out on Wistar rats.
Then, the effect of these essential oils was studied in the treatment of
experimental models induced by knee osteoarthritis. A radiographic and
Histologic analysis was carried out to monitor the efficiency of essential oil.
The
choice of the model of osteoarthritis turned to unilateral intra-articular
injection of a mono-iodo acetic acid.
Results: The results revealed that the action of
the essential oil showed a significant decrease in the Mankin score compared to
the group of untreated rats.
Conclusion: The essential
oils
of R. officinalis, P. alba presented an protective effect against
osteoarthritis with difference degrees.