Arezoo Mabhoot
1, Abolghasem Jouyban
2،3*1 Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
2 Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran
3 Kimia Idea Pardaz Azarbayjan (KIPA) Science Based Company, Tabriz Universit y of Medical Sciences, Tabriz, Iran
Abstract
Poor aqueous solubility of drugs is still
a challenging aspect in drug discovery and development. Solubilization
techniques such as cosolvency and complexation are used to solubilize
poorly soluble drugs. A number of mathematical models presented for predicting
the solubility of drugs in water+cosolvent mixtures and the Jouyban-Acree model
promises more accuracy when compared with other algorithms. Methods: Solubility
of sodium phenytoin in binary mixtures of propylene glycol + water in the
presence of beta-cyclodextrin (b-CD) along with the solubility of sodium
phenytoin in this solvent mixture in the
absence of b-CD using saturating shake flask method were studied. The
generated solubility data was fitted to the Jouyban-Acree model and the
solubility profile of drug in the presence of b-CD was compared with solubility data in
the absence of b-CD.
Results: The solubility was increased by addition of
propylene glycol and was decreased by addition of beta-cyclodextrin. The measured solubility data were used to evaluate
the correlation ability of the Jouyban-Acree model employing the solubility
data in monosolvent. These findings are supported by acceptable mean relative deviations values obtained when
comparing the estimated and experimental solubilities. Conclusion:
The addition of b-CD was decreased the solubilization power
of propylene glycol.