Manisha Pandey
1,2*, Hira Choudhury
1, Mohd Cairul Iqbal Mohd Amin
21 School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
2 Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia.
Abstract
Background: Preliminary safety evaluation
of polymer intended to use as drug delivery carrier is essential.
Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM)
hydrogel was prepared by microwave irradiation initiated free radical
polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity
and acute gastrointestinal toxicity studies to evaluate its biological safety
as potential oral drug delivery carrier.
Results: The results indicate that hydrogel was non cytotoxic and did not show
any histopathological changes in GI tract after a high dose of oral
administration.
Conclusion: The results revealed that hydrogel composed of bacterial cellulose and
polyacrylamide is safe as oral drug delivery carrier.