Pharm Sci. 2016;22(4): 291-295.
doi: 10.15171/PS.2016.45

Scopus ID: 85012885504
  Abstract View: 1374
  PDF Download: 671

Short Communication

Cytotoxicity and Acute Gastrointestinal Toxicity of Bacterial Cellulose-Poly (acrylamide-sodium acrylate) Hydrogel: A Carrier for Oral Drug Delivery

Manisha Pandey 1,2*, Hira Choudhury 1, Mohd Cairul Iqbal Mohd Amin 2

1 School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia.
2 Centre for Drug Delivery Research, Faculty of Pharmacy, Universiti Kebangsaan Malaysia.


Background: Preliminary safety evaluation of polymer intended to use as drug delivery carrier is essential. Methods: In this study polyacrylamide grafted bacterial cellulose (BC/AM) hydrogel was prepared by microwave irradiation initiated free radical polymerization. The synthesized hydrogel was subjected to in vitro cytotoxicity and acute gastrointestinal toxicity studies to evaluate its biological safety as potential oral drug delivery carrier. Results: The results indicate that hydrogel was non cytotoxic and did not show any histopathological changes in GI tract after a high dose of oral administration. Conclusion: The results revealed that hydrogel composed of bacterial cellulose and polyacrylamide is safe as oral drug delivery carrier.
Keywords: Bacterial cellulose, Polyacrylamide, Cytotoxicity, Acute oral toxicity, Microwave, Irradiation
First Name
Last Name
Email Address
Security code

Abstract View: 1375

Your browser does not support the canvas element.

PDF Download: 671

Your browser does not support the canvas element.

Submitted: 08 Aug 2016
Revision: 15 Sep 2016
Accepted: 17 Oct 2016
ePublished: 17 Oct 2016
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)