Pharm Sci. 2019;25(2):93-99.
doi: 10.15171/PS.2019.15
  Abstract View: 24
  PDF Download: 25

Research Article

Protective Effects of Aminoguanidine against Sodium Metavanadate-Induced Spatial Memory Retention Impairment in Morris Water Maze

Kaveh Tabrizian 1 ORCiD, Morteza Esmaeilei 2, Mahmoud Hashemzaei 1, Arezoo Esmaeilzaei 2, Sahar Fanoudi 3 * ORCiD, Mehdi Sanati 4, Maryam Belaran 5, Mehrafrooz Rigi 2, Ali Bazi 6, Najla Anvari 7, Ramin Rezaee 8

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
2 Students Research Committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
3 Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
4 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
5 Department of Physiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
6 Clinical Research Development Unit, Zabol University of Medical Sciences, Zabol, Iran.
7 Student Research Committee, Nursing and Midwifery School, Zabol University of Medical Sciences, Zabol, Iran.
8 Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Background: Vanadium is a potential neurotoxic agent widely distributed in the environment. Understanding the neurotoxic mechanisms of vanadium on learning and memory seems necessary. Methods: We investigated the time-dependent (1-week, 2- week and 4-week) effects of sodium metavanadate (SMV) (25 mg/kg/day; pre-training oral administration) and 4-day intraperitoneal injections of aminoguanidine (AG) as a selective inducible nitric oxide synthase inhibitor (10, 50, and 100 mg/kg) on spatial memory retention in Morris water maze. Animals were trained for 4 days and tested 48 h after the last training trial. Results: The data showed that 4-week oral pre-treatment with SMV (25 mg/kg/day) induced spatial memory retention deficits and decreased the time spent in the target quadrant. We found that 4-day administration of different doses of AG during training trials significantly decreased the time and distance of finding the hidden platforms. Additionally, SMV-induced spatial memory retention impairments were prevented in animals received combined SMV (25 mg/kg/day, 4 weeks) and AG (10 mg/kg/day, 4 days). Conclusion: Our findings showed the protective role of AG on SMV-induced spatial memory retention deficits.
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Submitted: 23 Jun 2018
Revised: 11 Dec 2018
Accepted: 17 Dec 2018
First published online: 30 Jun 2019
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