Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 32 3 2026 07 31 Solubility of Pharmaceutical Compounds in Binary Solvents: A Tutorial Review on Numerical Methods 332 337 10.34172/ps.43440 EN Elaheh Rahimpour https://orcid.org/0000-0002-4037-9436 Nima Nazemieh Tahir Suleymanov Jr. Acree https://orcid.org/William E. Abolghasem Jouyban https://orcid.org/0000-0002-4670-2783 REVIEW 10.34172/ps.43440 2025 11 01 2026 01 03 In this work the most widely used models applied for mathematical representation of the solubility data of pharmaceutical compounds in binary solvents were briefly reviewed. Then the utilizing SPSS software for solubility data modeling with some well-known mathematical models such as the van’t Hoff, the Apelblat, the combined nearly ideal binary solvent/Redlich-Kister, the Jouyban-Acree and the Jouyban-Acree-van’t Hoff, the modified Wilson, and the λh is described as a video file. The video is prepared in two parts. The first part is a general explanation of solubility and the importance of solubility data modeling. The second part describes how to use SPSS software for data modeling with the mentioned models.