Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 32 2 2026 04 30 Integrative Review of Vaccinium arctostaphylos L.: Phytochemical Composition, Biological Activities, Comparative Insights, and Future Development Prospects 185 200 10.34172/PS.026.42931 EN Negin Kamkar https://orcid.org/0009-0001-0104-4131 Faezeh Nemati https://orcid.org/0009-0009-5270-9349 Mohsen Farhadpour Mansour Miran Hadi Ghanbari https://orcid.org/0000-0003-1580-3829 Mozhgan Effat Panahi Reza Zadali https://orcid.org/0000-0003-0893-4345 REVIEW 10.34172/PS.026.42931 2025 07 26 2025 12 07 Vaccinium arctostaphylos L. (Ericaceae), is a medicinal shrub that commonly found in Caucasus and western Asia (Iran and Turkey). Traditionally, this plant has been employed for its antidiabetic and antihypertensive effects. Recent studies have indicated that V. arctostaphylos contains several important bioactive compounds, including terpenoids, anthocyanins, flavonoids, and phenolic acids, primarily found in its aerial parts. Although there is increasing evidence from laboratory and clinical studies supporting its beneficial effects on diabetes, hypertension, and hyperlipidemia, a comprehensive review of its ethnobotany, dietary value, chemical composition, pharmacological properties, and clinical applications remains lacking. This article serves as the first detailed review summarizing the current knowledge about V. arctostaphylos, encompassing its chemical constituents, biological activities, and findings from clinical trials. The information presented has been gathered from major scientific databases such as Google Scholar, Scopus, and PubMed. Overall, V. arctostaphylos presents a multifaceted therapeutic potential as a nutraceutical, offering complementary benefits in the modulation and management of complex metabolic disorders.