Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 31 1 2025 01 05 Vesicular Carriers for Follicular Drug Delivery 22 42 10.34172/PS.024.40827 EN Mostafa Amirinejad https://orcid.org/0000-0002-1054-7523 Atoosa Haghighizadeh Leila Etemad Omid Rajabi https://orcid.org/0000-0003-3127-2503 REVIEW 10.34172/PS.024.40827 2024 08 31 2024 11 07 The follicular route has been explored for both topical and systemic drug delivery but its application is challenged by different limitations such as sebum flow and size-selectivity. Vesicular carriers like liposomes, niosomes, invasomes, and transferosomes, which have shown promise in overcoming these barriers, have been explored in this review study. These vesicles improve follicular penetration of drugs, with deformable carriers performing better than conventional liposomes. Also, modifying liposomes using permeation enhancers has been introduced as another choice to enhance their follicular penetration. Vesicular systems have been primarily used to deliver drugs for treating alopecia, acne, and topical infections. They have also demonstrated potential in systemic delivery of antihypertensive drugs and insulin. Local hair massage and iontophoresis techniques further improve vesicle follicular penetration.