Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 30 2 2024 04 01 A Description on the Shake-Flask and Laser Monitoring-Based Techniques for Determination of the Drug’s Solubility 274 278 10.34172/PS.2024.2 EN Aynaz Zarghampour https://orcid.org/0000-0001-6903-8478 Kimiya Jouyban Vahid Jouyban-Gharamaleki Abolghasem Jouyban Elaheh Rahimpour https://orcid.org/0000-0002-4037-9436 Journal Article 10.34172/PS.2024.2 2023 11 01 2024 01 06 In the current work, the performance of the shake-flask and laser monitoring-based techniques for the determination of the solubility is described as a video file. The video is prepared in three parts. The first part is a general explanation of solubility and its manual and automatic measurement methods. The second part is about how to perform the shake-flask method to measure drug solubility, and the third part is about how the laser monitoring -based automatic device works to measure drug solubility.