Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 27 3 2021 09 01 Synthesis, Molecular Docking and Anticancer Activity of Novel 1,3-Thiazolidin-4-Ones 345 352 10.34172/PS.2020.95 EN Ramesh Sawant https://orcid.org/0000-0003-0064-7122 Jyoti Wadekar https://orcid.org/0000-0002-9341-0871 Rushikesh Ukirde Ganesh Barkade https://orcid.org/0000-0003-3836-3125 Journal Article 10.34172/PS.2020.95 2020 06 12 2020 11 19 Background: Cancer is a major cause of death all over the globe. Controlling cell division byinhibition of mitosis is the most successful clinical strategy for cancer treatment. The developmentof novel anticancer agents is the most important area in medicinal chemistry and drug discoveryresearch. Thiazolidine is the multifunctional nucleus which shows a number of pharmacologicalactivities like anticancer, anti-inflammatory, antioxidant, antibacterial, antifungal, antidiabetic,antihyperlipidemic and antiarthritic. Methods: In a present study series of 2-substituted-3-(1H-benzimidazole-2-yl)-thiazolidin-4-ones were designed, synthesized by the microwave-assisted system, and characterized bymelting point, IR, 1H NMR, and mass spectroscopy. All the newly synthesized compoundswere examined for their in vitro anticancer activity against breast cancer cell line MCF-7 bySulforhodamine B (SRB) assay. Results: The compounds AB-12 (GI50: 28.5 μg/ml) and AB-6 (GI50: 50.7 μg/ml) exhibitedsignificant cell growth inhibitory activity. Conclusion: These results indicate that compound AB-12 and AB-6 as related polo-like kinase1inhibitors compounds could be lead compounds for further development of anticanceragents.