Pharm Sci. 2022;28(1): 51-75.
doi: 10.34172/PS.2021.29

Scopus ID: 85127202300
  Abstract View: 429
  PDF Download: 445


Trado-Medical Uses, Chemical Constituents and Biological Activities of Newbouldia laevis (Bignoniaceae): A Review

Innocent U Okagu 1 ORCID logo, Joseph C Ndefo 2*, Matthias Onyebuchi Agbo 3* ORCID logo

1 Department of Biochemistry, University of Nigeria, Nsukka 410001, Nigeria.
2 Department of Science Laboratory Technology, University of Nigeria, Nsukka 410001, Nigeria.
3 Natural Products Chemistry Unit, Department of Pharmaceutical and Medicinal Chemistry, University of Nigeria, Nsukka 410001, Nigeria.
*Corresponding Authors: Email: joseph.ndefo@unn.edu.ng; Email: matthias.agbo@unn.edu.ng


Newbouldia laevis (P. Beauv.) Seem. (Family, Bignoniaceae), commonly known as tree of life, is a purple-flowering plant that is widely distributed in many parts of Africa. Different parts of the plant, including the leaves, flower, stems and roots are prevalently used in African traditional medicine for the management of many diseases and conditions like diabetes, hypertension, skin diseases, ulcer, tumors, pains, infectious diseases, inflammation, dysentery, sickle celldisease and impotency. This review discusses the trado-medical uses, chemical constituents, and biological activities of N. laevis. Based on information generated from scientific investigations deposited in PubMed and SCOPUS, the chemical constituents of the plant include glycosides, anthraquinolones, volatile oils, tannins, steroids, alkaloids, flavonoids, terpenoids and sterols. Extracts prepared from different parts of the plant of the plant and compounds isolated from them have been reported to have several health-promoting potentials such as antioxidant, antimalarial, trypanocidal, antimicrobial, anthelmintic, analgesic, anti-inflammatory, antidiabetic, antiarthritic,anti-thrombotic, cytoprotective, anti-hypertensive, central nervous system modulatory, male reproduction enhancing and oxytocic properties. These scientific investigations have led credence to the ethnobotanical uses of the plant in folkloric practice. In addition, the presence of phytochemical constituents in the plant might be responsible for the wide biological potentials.
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Submitted: 14 Jan 2021
Revision: 23 May 2021
Accepted: 24 May 2021
ePublished: 27 May 2021
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