Pharm Sci. 2022;28(1): 39-50.
doi: 10.34172/PS.2021.15

Scopus ID: 85127164794
  Abstract View: 364
  PDF Download: 438


Sodium Bicarbonate versus Statins to Prevent Contrast-induced Acute Kidney Injury: A Comprehensive Review

Sanam Dolati 1,2 ORCID logo, Ata Mahmoodpoor 3, Nafiseh Gharizadeh 2, Saina Gholipouri 4, Hassan Soleimanpour 5* ORCID logo

1 Physical Medicine and Rehabilitation Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Department of Anesthesiology and Critical Care Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
4 Department of Medical Sciences, University of Western Ontario, Ontario, Canada.
5 Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
*Corresponding Author: Email: h.soleimanpour@gmail.com


Iodinated contrast agents are commonly used in diagnostic radiography techniques along with therapeutic interventions. Contrast-Induced Acute Kidney Injury (CI-AKI) is a significant problem of all angiographic procedures, triggered by the use of Iodinated Contrast Media (ICM). There are conflicting data concerning the prevention and treatment of CI-AKI. Numerous approaches have been studied to prevent CI-AKI, but the therapy of choice remains undetermined. The cornerstones of CI-AKI prevention include low-osmolar ICM and intravenous hydration. The recommended hydration must be achieved by means of an isotonic solution of saline. Statins were tested against AKI due to their anti-inflammatory action and antioxidant effect on endothelial function. Novel approaches are required to investigate the short-term effects of high dosage atorvastatin versus sodium bicarbonate on CI-AKI prevention. The objective of this review is to compare the findings of various studies that had applied different doses of statins, sodium bicarbonate, and other agents for preventing CI-AKI.
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Abstract View: 364

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Submitted: 10 Nov 2020
Revision: 13 Mar 2021
Accepted: 19 Mar 2021
ePublished: 31 Mar 2021
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