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Pharm Sci. 2021;27(3): 339-344.
doi: 10.34172/PS.2020.89
  Abstract View: 217
  PDF Download: 30

Research Article

Effects of Sodium Selenite and Vitamin E on the Development of Morphine Dependency in Mice

Bohloul Habibi-Asl 1, Alireza Parvizpur 1, Kiarash Fekri 1,2, Hadis Jahanpanah 1, Hadis Rezaei 3, Mohammad Charkhpour 1* ORCID logo

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
2 Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3 Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

Abstract

Background: Antioxidant drugs may be useful in preventing morphine-induced dependency bysuppressing oxidative stress. Vitamin E which has many essential roles in the body is a powerfulantioxidant. On the other hand, selenium is an essential trace element that plays a strong rolein various biochemical pathways. The aim of this study was to investigate the effects of sodiumselenite and vitamin E on morphine-induced dependency in mice.

Methods: Ninety male mice, weighing 20 to 30 g, were randomly divided into 10 groups and weretreated as follows: a) saline and b) morphine groups were pretreated (for 2 days) with normalsaline (10 ml.kg-1.day-1, ip) then daily doses of normal saline (10 ml.kg-1.day-1, ip) and morphine(50 mg.kg-1.day-1) were added to the injections for the following 4 days, respectively. c, d, e)sodium selenite, f, g, h) vitamin E, i) vitamin E solvent (almond oil) and j) co-administrationgroups were pretreated (for 2 days) with sodium selenite (0.25, 0.5, 1 mg.kg-1.day-1, ip), vitaminE (20, 40, 60 IU.kg-1.day-1, ip), vitamin E solvent (10 ml.kg-1.day-1, ip) and combination of thedrugs respectively, then morphine doses (50 mg.kg-1.day-1, ip) were added to the injections forthe following 4 days. Withdrawal symptoms were evaluated after injecting naloxone (4 mg/kg/day). Biochemical evaluations were also performed.

Results: The results showed that co-administration of sodium selenite and vitamin E (at lowdoses) significantly reduced morphine dependency (p < 0.05).

Conclusion: The synergistic effect of sodium selenite and vitamin E can be a suitable andefficient approach to reduce dependency.

Keywords: Morphine, Sodium selenite, Vitamin E, Mice, Withdrawal syndrome
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Submitted: 15 Aug 2020
Revision: 27 Oct 2020
Accepted: 27 Oct 2020
ePublished: 29 Oct 2020
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