Pharm Sci. 2020;26(4): 434-440.
doi: 10.34172/PS.2020.27

Scopus ID: 85101495910
  Abstract View: 278
  PDF Download: 123

Research Article

Extraction of Cyproheptadine as Potent Appetizing Stimulant in Herbal Supplements by Efficient Carbon Nitride Nanosheets as Dispersive Solid Phase Extraction Adsorbent

Arezou Taghvimi 1 ORCID logo, Siavoush Dastmalchi 2,3, Yousef Javadzadeh 2* ORCID logo

1 Biotechnology Research Center and Student Research Committee, Tabriz University of Medical Science, Tabriz, Iran.
2 Biotechnology Research Center and Faculty of Pharmacy, Tabriz University of Medical Science, Tabriz, Iran.
3 Faculty of Pharmacy, Near East University, POBOX: 99138, Nicosia, North Cyprus, Mersin 10, Turkey.


Background: Application of natural-based herbal medicine is on a growing trend in some countries and people prefer to use plant-originated drugs rather than chemical-based ones. The present study describes an interesting sample preparation method for extraction and determination of cyproheptadine in herbal supplements as appetizing stimulant by using carbon nitride nanosheets as dispersive solid phase extraction method coupled with HPLCUV.
Methods: Various techniques used for characterization of adsorbent such as: Infrared spectroscopy (IR), scanning electron microscopy (SEM), Zeta potential analysis and powder X-ray diffraction (XRD). Optimization of the important extraction parameters were conducted by one parameter-at-a time method. Next, method validation was carried out.
Results: The optimized cyproheptadine extraction parameters were introduced and under optimized conditions the method presented a good linearity in the concentration range of 300-2000 ng/g. The limit of detection (LOD) was 100 ng/g for the introduced method.
Conclusion: Quantitative analysis of fifteen real samples (Tablets or capsules) by proposed method confirmed the illegal presence of cyproheptadine in herbal appetizing stimulants supplements of the markets.
Keywords: Appetizing Stimulant, Herbal Supplement, Cyrproheptadine, Carbon Nitride Nanosheets, HPLC
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Submitted: 28 Dec 2019
Revision: 19 Mar 2020
Accepted: 19 Mar 2020
ePublished: 25 Dec 2020
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