Pharm Sci. 2019;25(4): 364-368.
doi: 10.15171/PS.2019.33

Scopus ID: 85077595130
  Abstract View: 706
  PDF Download: 360

Short Communication

Flavonoids from the Aerial Parts of Artemisia biennis Willd

Kazhal Rostami Dehmoradkhani 1, Azizollah Jafari 2, Yalda Shokoohinia 3, Seyed Ahmad Emami 4, Mahdi Mojarrab 3* ORCID logo

1 Department of Chemistry, Faculty of Sciences, University of Yasouj, Yasouj, Iran.
2 Department of Biology, Faculty of Sciences, University of Yasouj, Yasouj, Iran.
3 Pharrmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4 Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.


Background: The current phytochemical study was carried out on a fraction of dried polar extract of aerial parts of Artemisia biennis Willd. which was previously reported to decrease the viability of the rat pheochromocytoma cell line PC12 in cell-based antioxidant assays. Methods: A combination of solid phase extraction (SPE) and high pressure liquid chromatography (HPLC) of the hydroethanolic extract was used to purify the compounds. Structures of the isolated compounds were elucidated by spectroscopic means, including 1H-NMR and MS analyses. Results: Three isolated and identified flavonoids in this study were luteolin, kaempferol and apigenin. Conclusion: The cytotoxic potential of flavone aglycones, as the major components of selected fraction in the hydroethanolic extract of A. biennis might partly be related to the high death rate of PC12 cells.
Keywords: Artemisia biennis, Luteolin, kaempferol, Apigenin, PC12 cell line
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Submitted: 19 Jan 2019
Revision: 19 Mar 2019
Accepted: 10 Apr 2019
ePublished: 20 Dec 2019
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