Azar Mostoufi
1,2,3, Neda Bavarsad
4,5*, Sahar Aryanfar
3, Abbas Akhgari
61 Marine Pharmaceutical Science Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2 Department of Medicinal Chemistry, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
3 Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
4 Nanotechnology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
5 Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6 Targeted Drug Delivery Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
Background: Antacids are the most
commonly used medications for fast symptomatic relief of gastric disorders.
Because of adverse effects, low efficiency and the high cost of some chemical antacids, identifying a natural medicine
with high efficiency and low cost seems
useful. Therefore, the aim of the present study
was to prepare antacid tablets from Cuttlefish bone and assessment of its
antacid properties.
Methods: 24 different
formulations of cuttlefish bone were prepared by direct compression using
different fillers (starch, cellulose, lactose, and
mixture of those) in different ratios of the drug. Characterization of powders
and tablets was done on all formulations and marketed dosage forms (calcium
carbonate and Al-Mg).
Results: Weight uniformity,
hardness, and friability of all
formulations were in acceptable range. Tablets prepared by calcined cuttlebone disintegrated in longer time due to
their higher hardness which were mostly
higher than 5 Kg. Also, disintegration
time of formulations 50-50 (lower dose of cuttlebone) was less than other
tablets (2 minutes or less). Results of antacid capacity showed that
formulations 90-10 and 80-20 raise the acidic pH of the medium above 7.5, which were the same as or more than the capacity of the marketed tablets.